4,4'-Methylenedianiline

4,4'-Methylenedianiline

SCHEMBL28001

Nc1ccc(Cc2ccc(N)cc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 1.00
ALDH1A1 P00352 2/20 1.00
TDP1 Q9NUW8 2/20 1.00
TSHR P16473 1/20 1.00
GFER P55789 1/20 0.65
LOXL2 Q9Y4K0 1/20 0.61
CYP17A1 P05093 1/20 0.61
CYP19A1 P11511 1/20 0.61
CYP11B1 P15538 1/20 0.61
CYP11B2 P19099 1/20 0.61
MEN1 O00255 1/20 0.57
MAPT P10636 1/20 0.57
KMT2A Q03164 1/20 0.57
CA12 O43570 1/20 0.54
CA1 P00915 1/20 0.54
CA2 P00918 1/20 0.54
CA9 Q16790 1/20 0.54
CA14 Q9ULX7 1/20 0.54
MAOB P27338 4/20 0.52
MAOA P21397 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8094139 1.00 CYP3A4 (1.00) CYP3A4ALDH1A1TDP1TSHRGFER
SCHEMBL6362775 1.00 CYP3A4 (1.00) CYP3A4ALDH1A1TDP1TSHRGFER
4,4'-Methylenedianiline SCHEMBL15105282 1.00 CYP3A4 (1.00) CYP3A4ALDH1A1TDP1TSHRGFER
SCHEMBL1304762 1.00 CYP3A4 (1.00) CYP3A4ALDH1A1TDP1TSHRGFER
SCHEMBL3482770 1.00 CYP3A4 (1.00) CYP3A4ALDH1A1TDP1TSHRGFER
4,4'-Methylenedianiline SCHEMBL2529236 0.97 CYP3A4 (0.93) CYP3A4ALDH1A1TDP1TSHRGFER
4,4'-Methylenedianiline SCHEMBL4062058 0.97 CYP3A4 (0.93) CYP3A4ALDH1A1TDP1TSHRGFER
4,4'-Methylenedianiline SCHEMBL9770941 0.97 CYP3A4 (0.93) CYP3A4ALDH1A1TDP1TSHRGFER
4,4'-Methylenedianiline SCHEMBL10896251 0.97 CYP3A4 (0.93) CYP3A4ALDH1A1TDP1TSHRGFER
4,4'-Methylenedianiline SCHEMBL6424891 0.97 CYP3A4 (0.93) CYP3A4ALDH1A1TDP1TSHRGFER

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 53993 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122080639-A Wide-temperature-range pressure heating silicone rubber material for vehicle and preparation method thereof 2026-05-26 CN claimed
CN-122080724-A Epoxy resin-based composite impermeable material and preparation method and application thereof 2026-05-26 CN claimed
CN-122071402-A Preparation method and application of 4,4' -difluoro diphenyl methane 广州天赐高新材料股份有限公司 2026-05-22 CN claimed
US-20260139168-A1 ONE COMPONENT EPOXY ADHESIVE COMPOSITION HENKEL AG & CO KGAA (DE) 2026-05-21 US claimed
EP-4743528-A1 ONE COMPONENT EPOXY ADHESIVE COMPOSITION Henkel AG & Co. KGaA (DE) 2026-05-20 EP claimed
CN-119240857-B Hydrophobic oleophylic modified sponge, preparation method and application thereof in oil-water separation 南昌大学 2026-05-19 CN claimed
CN-116874742-B Curable epoxy resin composition and preparation method and application thereof 万华化学集团股份有限公司 2026-05-19 CN claimed
CN-122060171-A Preparation method and application of nitrogen/phosphorus covalent organic framework flame retardant 福建师范大学 2026-05-19 CN claimed
WO-2026099226-A1 METHOD FOR RECOVERING VALUABLE MATERIALS FROM POLYURETHANE FOAMS COVESTRO DEUTSCHLAND AG (DE) 2026-05-15 WO claimed
CN-122037454-A Preparation method of furan resin adhesive material for low-gas-release 3D printing sand mold 运城学院 2026-05-15 CN claimed
US-3959374-A CONTINUOUS JEFFERSON CHEMICAL COMPANY, INC. (US) 1976-05-25 US claimed
US-3954867-A ANILINE-FORMALDEHYDE POLYMER DOW CHEMICAL COMPANY, THE 1976-05-04 US claimed
US-3950279-A DI- OR TRI-MALEIMIDE, AZOMETHINE, SOLID FOAMING AGENT CIBA-GEIGY CORPORATION (US) 1976-04-13 US claimed
US-3949764-A Treatment of natural and synthetic hair with a heat-settable composition FABALON, INC. (US) 1976-04-13 US claimed
US-3947493-A Process for the production of maleamic acids RHONE-POULENC, S.A. (FR) 1976-03-30 US claimed
US-3947484-A Continuous prephosgenation process for the production of organic isocyanates BAYER AKTIENGESELLSCHAFT (DT) 1976-03-30 US claimed
US-3947385-A Mixtures containing prepolymers, which can be converted to heat-resistant foamed plastics CIBA-GEIGY CORPORATION (US) 1976-03-30 US claimed
US-3945999-A Process for preparing solid bis-(4-furfurylidenamino-phenyl)-methane RHONE-POULENC, S.A. (FR) 1976-03-23 US claimed
US-3943107-A Processable high temperature polymers prepared from amine terminated polymers and cyanamides of polyfunctional secondary amines CIBA-GEIGY CORPORATION (US) 1976-03-09 US claimed
US-3932364-A DIHYDROCARBYL PHOSPHITE AND A PYRIDINE SUMITOMO CHEMICAL COMPANY, LIMITED (JA) 1976-01-13 US claimed