4,4'-Methylenedianiline

4,4'-Methylenedianiline

SCHEMBL2529236

N.N.Nc1ccc(Cc2ccc(N)cc2)cc1

nearest known ligand 0.93

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.93
ALDH1A1 P00352 2/20 0.93
TDP1 Q9NUW8 2/20 0.93
TSHR P16473 1/20 0.93
GFER P55789 1/20 0.61
CYP19A1 P11511 2/20 0.58
CYP17A1 P05093 1/20 0.58
CYP11B1 P15538 1/20 0.58
CYP11B2 P19099 1/20 0.58
LOXL2 Q9Y4K0 1/20 0.58
MEN1 O00255 1/20 0.53
MAPT P10636 1/20 0.53
KMT2A Q03164 1/20 0.53
CA12 O43570 1/20 0.52
CA1 P00915 1/20 0.52
CA2 P00918 1/20 0.52
CA9 Q16790 1/20 0.52
CA14 Q9ULX7 1/20 0.52
MAOB P27338 4/20 0.50
MAOA P21397 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
4,4'-Methylenedianiline SCHEMBL4062058 1.00 CYP3A4 (0.93) CYP3A4ALDH1A1TDP1TSHRGFER
SCHEMBL8094139 0.97 CYP3A4 (1.00) CYP3A4ALDH1A1TDP1TSHRGFER
SCHEMBL1304762 0.97 CYP3A4 (1.00) CYP3A4ALDH1A1TDP1TSHRGFER
4,4'-Methylenedianiline SCHEMBL15105282 0.97 CYP3A4 (1.00) CYP3A4ALDH1A1TDP1TSHRGFER
4,4'-Methylenedianiline SCHEMBL28001 0.97 CYP3A4 (1.00) CYP3A4ALDH1A1TDP1TSHRGFER
SCHEMBL3482770 0.97 CYP3A4 (1.00) CYP3A4ALDH1A1TDP1TSHRGFER
SCHEMBL6362775 0.97 CYP3A4 (1.00) CYP3A4ALDH1A1TDP1TSHRGFER
4,4'-Methylenedianiline SCHEMBL9770941 0.93 CYP3A4 (0.93) CYP3A4ALDH1A1TDP1TSHRGFER
4,4'-Methylenedianiline SCHEMBL10896251 0.93 CYP3A4 (0.93) CYP3A4ALDH1A1TDP1TSHRGFER
4,4'-Methylenedianiline SCHEMBL6424891 0.93 CYP3A4 (0.93) CYP3A4ALDH1A1TDP1TSHRGFER

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2511921-B1 Film capacitor element, film capacitor, and method of producing the film capacitor element KOJIMA PRESS KOGYO KK (JP) 2016-06-22 EP claimed
EP-0886663-A1 BISMALEIMIDE RESINS CONTAINING LESS THAN 0.1 WT % FREE AROMATIC DIAMINE Hos-Technik Ing.Mag. Heinz Schwarzl (AT) 1998-12-30 EP claimed
WO-1997033933-A1 BISMALEIMIDE RESINS CONTAINING LESS THAN 0.1 WT % FREE AROMATIC DIAMINE HOS-TECHNIK (AT) 1997-09-18 WO claimed
EP-0097411-B1 FOAMED POLYIMIDE AND POLYAMIDE-IMIDE, AND PRODUCTION THEREOF Gagliani, John (US) 1986-07-02 EP claimed
EP-3071424-B1 POLYURETHANE SUPPORT FOR NON-PNEUMATIC TIRE MICHELIN & CIE (FR) 2021-05-26 EP disclosed
CN-109456621-A Organic modified sheet silicate and preparation method thereof 中南大学 2019-03-12 CN disclosed
US-9791348-B2 Sensor for wear measurement, method for making same, and method for operating same NAVY, DEPARTMENT OF THE 2017-10-17 US disclosed
US-20160288569-A1 POLYURETHANE SUPPORT FOR NON-PNEUMATIC TIRE COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2016-10-06 US disclosed
EP-3071424-A1 POLYURETHANE SUPPORT FOR NON-PNEUMATIC TIRE Compagnie Générale des Etablissements Michelin (FR) 2016-09-28 EP disclosed
WO-2015077438-A1 POLYURETHANE SUPPORT FOR NON-PNEUMATIC TIRE COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2015-05-28 WO disclosed
US-20150049970-A1 SENSOR FOR WEAR MEASUREMENT, METHOD FOR MAKING SAME, AND METHOD FOR OPERATING SAME NAVY, DEPARTMENT OF THE 2015-02-19 US disclosed
US-8703882-B2 Phosphorus-containing benzoxazine-based bisphenols, derivatives thereof, and preparing method for the same NATIONAL CHUNGHSING UNIVERSITY (TW) 2014-04-22 US disclosed
US-20120292803-A1 GOLF BALL BRIDGESTONE SPORTS CO., LTD. (JP) 2012-11-22 US disclosed
US-20110257347-A1 Phosphorus-containing benzoxazine-based bisphenols, derivatives thereof, and preparing method for the same NATIONAL CHUNGHSING UNIVERSITY (TW) 2011-10-20 US disclosed
EP-1375591-B1 Method for producing a fiber reinforced product with an epoxy-based matrix HEXION SPECIALTY CHEM GMBH (DE) 2008-09-17 EP disclosed
EP-1375591-A2 Method for producing a fiber reinforced product with an epoxy-based matrix Bakelite AG (DE) 2004-01-02 EP disclosed
EP-0166321-A2 Hydrophobic polyamides BAYER AG (DE) 1986-01-02 EP disclosed
EP-0107800-A2 Process for preparing a solution of a putty resin HOECHST AKTIENGESELLSCHAFT (DE) 1984-05-09 EP disclosed
US-4241131-A Moldable polyurethane foam-backed fabrics MOBAY CHEMICAL CORPORATION (US) 1980-12-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110257347-A1 Phosphorus-containing benzoxazine-based bisphenols, derivatives thereof, and preparing method for the same P2RX4, P2RX1, DHX15 CYP3A4 375/4885ALDH1A1 1551/4885TDP1 965/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.