Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1066576 | 0.91 | TSHR (0.67) | TSHRTDP1ESR1ESR2SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1409425 | 0.89 | TSHR (0.64) | TSHRTDP1ESR1ESR2ALDH1A1 | |
| Water SCHEMBL28780406 | 0.89 | TSHR (0.64) | TSHRTDP1ESR1ESR2ALDH1A1 | |
| Phenol SCHEMBL28177872 | 0.88 | TSHR (0.56) | TSHRTDP1ESR1ESR2SMN1; SMN2 | |
| Acetic Acid Methyl Ester SCHEMBL28085684 | 0.87 | ALDH1A1 (0.55) | TSHRTDP1ESR1ESR2SMN1; SMN2 | |
| SCHEMBL6744772 | 0.86 | ESR1 (0.54) | TSHRTDP1ESR1ESR2L3MBTL1 | |
| SCHEMBL1837574 | 0.86 | ESR1 (0.54) | TSHRTDP1ESR1ESR2L3MBTL1 | |
| SCHEMBL7506958 | 0.85 | TSHR (0.71) | TSHRTDP1ESR1ESR2SMN1; SMN2 | |
| SCHEMBL15899173 | 0.84 | FFAR1 (0.50) | TSHRTDP1ESR1ESR2L3MBTL1 | |
| SCHEMBL4168034 | 0.84 | TSHR (0.54) | TSHRTDP1ESR1ESR2HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105837714-B | The manufacturing method of solid catalyst component for olefin polymerization, the manufacturing method of polymerization of olefines catalyst and olefin polymer | 东邦钛株式会社 | 2018-07-20 | — | — | CN | disclosed |
| CN-108290974-A | The manufacturing method of polymerization of olefines catalyst | 东邦钛株式会社 | 2018-07-17 | — | — | CN | disclosed |
| CN-104640886-B | The manufacture method of manufacture method for the ingredient of solid catalyst of olefin polymerization, the catalyst for olefin polymerization and olefin polymerization | 东邦钛株式会社 | 2018-04-27 | — | — | CN | disclosed |
| CN-104822712-B | Solid catalyst component for polymerizing olefin, catalyst for polymerizing olefin, and method for producing polymerized olefin | 东邦钛株式会社 | 2018-02-23 | — | — | CN | disclosed |
| CN-104470953-B | Process for producing solid catalyst component for olefin polymerization, catalyst for olefin polymerization, and process for producing olefin polymer | 东邦钛株式会社 | 2017-11-14 | — | — | CN | disclosed |
| CN-107207646-A | Solid catalyst component for olefin polymerization, process for producing olefin polymerization catalyst, and process for producing olefin polymer | 东邦钛株式会社 | 2017-09-26 | — | — | CN | disclosed |
| CN-107207645-A | The manufacture method of polymerization of olefines catalyst and the manufacture method of olefin polymer | 东邦钛株式会社 | 2017-09-26 | — | — | CN | disclosed |
| CN-104640887-B | The manufacture method of manufacture method for the ingredient of solid catalyst of olefin polymerization, the catalyst for olefin polymerization and olefin polymerization | 东邦钛株式会社 | 2017-08-29 | — | — | CN | disclosed |
| CN-106414515-A | Solid catalyst component for use in polymerization of olefins, method for producing same, catalyst for use in polymerization of olefins, and method for producing olefin polymer | 东邦钛株式会社 | 2017-02-15 | — | — | CN | disclosed |
| CN-103764689-B | The manufacture method of solid catalyst component for olefin polymerization, polymerization of olefines catalyzer and olefin polymer | TOHO TITANIUM CO.,LTD. (JP) | 2016-03-30 | — | — | CN | disclosed |
| CN-105008407-A | Process for producing propylene block copolymer | TOHO TITANIUM CO LTD | 2015-10-28 | — | — | CN | disclosed |
| CN-104822712-A | Solid catalyst component for polymerizing olefin, catalyst for polymerizing olefin, and method for producing polymerized olefin | TOHO TITANIUM CO LTD | 2015-08-05 | — | — | CN | disclosed |
| CN-104640887-A | Production method for solid catalyst component for polymerizing olefins, catalyst for polymerizing olefins, and production method for polymerized olefins | TOHO TITANIUM CO LTD | 2015-05-20 | — | — | CN | disclosed |
| CN-104640886-A | PRODUCTION METHOD FOR SOLID CATALYST COMPONENT FOR POLYMERIZING OLEFINS, CATALYST FOR POLYMERIZING OLEFINS, AND PRODUCTION METHOD FOR POLYMERIZED OLEFINS | TOHO TITANIUM CO LTD | 2015-05-20 | — | — | CN | disclosed |
| CN-104470953-A | Process for producing solid catalyst component for olefin polymerization, catalyst for olefin polymerization, and process for producing olefin polymer | TOHO TITANIUM CO LTD | 2015-03-25 | — | — | CN | disclosed |