Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14918845 | 0.84 | P4HTM (0.50) | MAPK1KDM4EL3MBTL1P4HTMLMNA | |
| SCHEMBL28810482 | 0.82 | MAPK1 (0.43) | MAPK1KDM4EL3MBTL1LCKP4HTM | |
| SCHEMBL12481577 | 0.81 | MAPK1 (0.54) | MAPK1KDM4EL3MBTL1LCKP4HTM | |
| SCHEMBL9901479 | 0.79 | MAPK1 (0.59) | MAPK1KDM4EL3MBTL1LCKP4HTM | |
| SCHEMBL30555263 | 0.79 | MAPK1 (0.59) | MAPK1KDM4EL3MBTL1LCKP4HTM | |
| SCHEMBL29926516 | 0.77 | MAPK1 (0.57) | MAPK1KDM4EL3MBTL1LCKP4HTM | |
| SCHEMBL2586496 | 0.77 | CA12 (0.53) | MAPK1CA12CA1CA2CA9 | |
| SCHEMBL3153788 | 0.77 | MAPK1 (0.57) | MAPK1KDM4EL3MBTL1LCKP4HTM | |
| SCHEMBL2304195 | 0.77 | MAPK1 (0.57) | MAPK1KDM4EL3MBTL1LCKCA12 | |
| SCHEMBL19249701 | 0.75 | MAPK1 (0.54) | MAPK1KDM4EL3MBTL1P4HTMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106349156-B | It can be used as the pyridine -2- amides of CB2 agonist | 霍夫曼-拉罗奇有限公司 | 2018-12-11 | — | — | CN | disclosed |
| CN-104854092-B | Pyridine-2-amides useful as CB2 agonists | 霍夫曼-拉罗奇有限公司 | 2018-08-10 | — | — | CN | disclosed |
| CN-107674061-A | Pyridine derivate | 霍夫曼-拉罗奇有限公司 | 2018-02-09 | — | — | CN | disclosed |
| CN-104837831-B | Novel pyridine derivatives | 霍夫曼-拉罗奇有限公司 | 2017-10-31 | — | — | CN | disclosed |
| CN-106349156-A | Pyridine-2-amides capable of being used as CB2 agonist | 霍夫曼-拉罗奇有限公司 | 2017-01-25 | — | — | CN | disclosed |
| CN-103608332-B | Pyridine-2-amides useful as CB2 agonists | 霍夫曼-拉罗奇有限公司 | 2016-09-28 | — | — | CN | disclosed |
| CN-104854092-A | PYRIDINE-2-AMIDES USEFUL AS CB2 AGONISTS | HOFFMANN LA ROCHE | 2015-08-19 | — | — | CN | disclosed |
| CN-104837831-A | Novel pyridine derivatives | HOFFMANN LA ROCHE | 2015-08-12 | — | — | CN | disclosed |