Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.33 |
| ▸ | MAPT | P10636 | 12/20 | 0.33 |
| ▸ | LMNA | P02545 | 6/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
| ▸ | PPARD | Q03181 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13763088 | 0.88 | CYP1A2 (0.34) | TP53MAPTLMNATHRBFFAR1 | |
| SCHEMBL280498 | 0.85 | MAPT (0.35) | TP53MAPTLMNATHRB | |
| SCHEMBL280310 | 0.83 | MAPT (0.35) | TP53MAPTLMNATHRBFFAR1 | |
| SCHEMBL279124 | 0.82 | LMNA (0.39) | TP53MAPTLMNATHRBPPARD | |
| SCHEMBL279879 | 0.81 | LMNA (0.41) | TP53MAPTLMNATHRB | |
| SCHEMBL279358 | 0.80 | TP53 (0.34) | TP53MAPTLMNATHRBFFAR1 | |
| SCHEMBL280290 | 0.80 | MAPT (0.39) | TP53MAPTLMNATHRB | |
| SCHEMBL280047 | 0.80 | FFAR1 (0.46) | TP53MAPTLMNATHRBFFAR1 | |
| SCHEMBL280469 | 0.80 | SCN3A (0.39) | TP53MAPTLMNATHRB | |
| SCHEMBL279517 | 0.79 | LMNA (0.39) | TP53MAPTLMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8134010-B2 | 4-[4-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-phenylamine; N-{4-[4-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-phenyl}-acetamide; or4-Methyl-5-(2-nitrooxy-ethyl)-2-(4-nitro-phenyl)-thiazole; cardiovascular, gastrointestinal, inflammatory, respiratory disease | RENOPHARM LTD. (IL) | 2012-03-13 | — | — | US | disclosed |
| US-7968575-B2 | Nitric oxide donors and uses thereof | RENOPHARM LTD. (IL) | 2011-06-28 | — | — | US | disclosed |
| US-7579477-B2 | Thiazole-based nitric oxide donors having alkyl substituent(s) and uses thereof | RENOPHARM LTD. (IL) | 2009-08-25 | — | — | US | disclosed |
| US-7498445-B2 | Thiazole-based nitric oxide donors capable of releasing two or more nitric oxide molecules and uses thereof | RENOPHARM LTD. (IL) | 2009-03-03 | — | — | US | disclosed |
| US-7368577-B2 | Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof | RENOPHARM LTD. (IL) | 2008-05-06 | — | — | US | disclosed |
| US-7332513-B2 | Thiazole-based nitric oxide donors having acyl substituent(s) and uses thereof | RENOPHARM LTD. (IL) | 2008-02-19 | — | — | US | disclosed |