Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.76 |
| ▸ | PDE5A | O76074 | 17/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | PDE2A | O00408 | 2/20 | 0.67 |
| ▸ | PDE9A | O76083 | 2/20 | 0.67 |
| ▸ | PDE4A | P27815 | 2/20 | 0.67 |
| ▸ | PDE6C | P51160 | 2/20 | 0.67 |
| ▸ | PDE1A | P54750 | 2/20 | 0.67 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.67 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.65 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.65 |
| ▸ | PDE6D | O43924 | 1/20 | 0.65 |
| ▸ | PDE8A | O60658 | 1/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | HTR1A | P08908 | 1/20 | 0.65 |
| ▸ | PDE6A | P16499 | 1/20 | 0.65 |
| ▸ | PDE6G | P18545 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2795731 | 0.95 | KDM4E (0.68) | KDM4EPDE5AKMT2APDE2APDE9A | |
| SCHEMBL7094034 | 0.91 | KDM4E (0.83) | KDM4EPDE5AKMT2APDE2APDE9A | |
| SCHEMBL2800945 | 0.88 | KDM4E (0.69) | KDM4EPDE5AKMT2APDE2APDE9A | |
| SCHEMBL2800172 | 0.87 | KDM4E (0.73) | KDM4EPDE5AKMT2APDE2APDE9A | |
| SCHEMBL2803557 | 0.87 | PDE5A (0.69) | KDM4EPDE5AKMT2APDE2APDE9A | |
| SCHEMBL25013455 | 0.86 | PDE5A (0.91) | KDM4EPDE5AKMT2APDE2APDE9A | |
| SCHEMBL2806791 | 0.85 | KDM4E (0.77) | KDM4EPDE5AKMT2APDE2APDE9A | |
| SCHEMBL2798451 | 0.85 | KDM4E (0.69) | KDM4EPDE5AKMT2APDE2APDE9A | |
| SCHEMBL2800423 | 0.85 | KDM4E (0.77) | KDM4EPDE5AKMT2APDE2APDE9A | |
| SCHEMBL2799404 | 0.84 | PDE5A (0.75) | KDM4EPDE5AKMT2APDE2APDE9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2253632-B1 | Pyrazolopyramidinone derivatives, their preparation and their use | TOPHARMAN SHANGHAI CO LTD (CN) | 2012-05-23 | — | — | EP | disclosed |
| EP-2253632-A1 | Pyrazolopyramidinone derivatives, their preparation and their use | Topharman Shanghai Co., Ltd. (CN) | 2010-11-24 | — | — | EP | disclosed |
| EP-1961753-A1 | PYRAZOLOPYRIMIDINONE DERIVATIVES, THEIR PREPARATION AND THEIR USE | Topharman Shanghai Co., Ltd. (CN) | 2008-08-27 | — | — | EP | disclosed |