Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.77 |
| ▸ | PDE5A | O76074 | 17/20 | 0.76 |
| ▸ | PDE2A | O00408 | 2/20 | 0.73 |
| ▸ | PDE9A | O76083 | 2/20 | 0.73 |
| ▸ | PDE4A | P27815 | 2/20 | 0.73 |
| ▸ | PDE6C | P51160 | 2/20 | 0.73 |
| ▸ | PDE1A | P54750 | 2/20 | 0.73 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.73 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.73 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.70 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.70 |
| ▸ | PDE6D | O43924 | 1/20 | 0.70 |
| ▸ | PDE8A | O60658 | 1/20 | 0.70 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | HTR1A | P08908 | 1/20 | 0.70 |
| ▸ | PDE6A | P16499 | 1/20 | 0.70 |
| ▸ | PDE6G | P18545 | 1/20 | 0.70 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2800689 | 0.91 | KDM4E (0.76) | KDM4EKMT2APDE5APDE2APDE9A | |
| SCHEMBL2800423 | 0.90 | KDM4E (0.77) | KDM4EKMT2APDE5APDE2APDE9A | |
| SCHEMBL2806791 | 0.90 | KDM4E (0.77) | KDM4EKMT2APDE5APDE2APDE9A | |
| SCHEMBL2800172 | 0.89 | KDM4E (0.73) | KDM4EKMT2APDE5APDE2APDE9A | |
| SCHEMBL2799404 | 0.88 | PDE5A (0.75) | KDM4EKMT2APDE5APDE2APDE9A | |
| SCHEMBL6628860 | 0.88 | KMT2A (0.85) | KDM4EKMT2APDE5APDE2APDE9A | |
| SCHEMBL28542006 | 0.87 | KMT2A (0.78) | KDM4EKMT2APDE5APDE2APDE9A | |
| SCHEMBL1071 | 0.87 | KMT2A (0.83) | KDM4EKMT2APDE5APDE2APDE9A | |
| SCHEMBL21995693 | 0.87 | KMT2A (0.83) | KDM4EKMT2APDE5APDE2APDE9A | |
| SCHEMBL29655374 | 0.87 | KMT2A (0.83) | KDM4EKMT2APDE5APDE2APDE9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129093-B1 | PYRAZOLOPYRIMIDINONE DERIVATIVES FOR THE TREATMENT OF IMPOTENCE | DONG A PHARM CO LTD (KR) | 2003-07-23 | — | — | EP | claimed |
| EP-1129093-B1 | PYRAZOLOPYRIMIDINONE DERIVATIVES FOR THE TREATMENT OF IMPOTENCE | DONG A PHARM CO LTD (KR) | 2003-07-23 | — | — | EP | disclosed |