Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | VDR | P11473 | 10/20 | 0.36 |
| ▸ | AR | P10275 | 7/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28008532 | 0.77 | NCF1 (0.35) | CYP1A2KDM4ELMNAMEN1CYP2C19 | |
| SCHEMBL28008218 | 0.73 | CYP1A2 (0.48) | CYP1A2KDM4EAGTR1LMNATSHR | |
| SCHEMBL9934389 | 0.68 | CYP1A2 (0.50) | CYP1A2KDM4EAGTR1LMNATSHR | |
| Mephenesin SCHEMBL28316204 | 0.68 | CYP1A2 (0.75) | CYP1A2KDM4EAGTR1LMNAMEN1 | |
| Mephenesin SCHEMBL29379669 | 0.67 | CYP1A2 (1.00) | CYP1A2KDM4EAGTR1LMNAMEN1 | |
| Mephenesin SCHEMBL6482337 | 0.67 | CYP1A2 (1.00) | CYP1A2KDM4EAGTR1LMNAMEN1 | |
| Mephenesin SCHEMBL332864 | 0.67 | CYP1A2 (1.00) | CYP1A2KDM4EAGTR1LMNAMEN1 | |
| Mephenesin SCHEMBL25448 | 0.67 | CYP1A2 (1.00) | CYP1A2KDM4EAGTR1LMNAMEN1 | |
| SCHEMBL6601291 | 0.66 | CYP1A2 (0.49) | CYP1A2KDM4EAGTR1LMNATSHR | |
| SCHEMBL13412634 | 0.65 | CYP1A2 (0.60) | CYP1A2KDM4EAGTR1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104710381-A | Novel 3-hydroxy-5-arylisothiazole derivative | MOCHIDA PHARM CO LTD | 2015-06-17 | — | — | CN | claimed |
| CN-102712610-B | Novel 3-hydroxy-5-arylisothiazole derivatives | MOCHIDA PHARM CO LTD | 2015-03-04 | — | — | CN | claimed |
| CN-104710381-A | Novel 3-hydroxy-5-arylisothiazole derivative | MOCHIDA PHARM CO LTD | 2015-06-17 | — | — | CN | disclosed |
| CN-102712610-B | Novel 3-hydroxy-5-arylisothiazole derivatives | MOCHIDA PHARM CO LTD | 2015-03-04 | — | — | CN | disclosed |