Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | XDH | P47989 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | CCR6 | P51684 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1524510 | 0.87 | EGFR (0.74) | EGFRMAPTNPC1RAB9AXDH | |
| SCHEMBL28582218 | 0.87 | EGFR (0.74) | EGFRMAPTNPC1RAB9AXDH | |
| SCHEMBL1524509 | 0.87 | EGFR (0.74) | EGFRMAPTNPC1RAB9AXDH | |
| SCHEMBL30825572 | 0.87 | EGFR (0.74) | EGFRMAPTNPC1RAB9AXDH | |
| SCHEMBL28009966 | 0.86 | MAPT (0.58) | EGFRMAPTNPC1RAB9AHPGD | |
| SCHEMBL28010604 | 0.86 | MAPT (0.68) | EGFRMAPTNPC1RAB9AHPGD | |
| SCHEMBL3138953 | 0.84 | EGFR (0.72) | EGFRMAPTNPC1RAB9AHPGD | |
| SCHEMBL28430681 | 0.84 | EGFR (0.72) | EGFRMAPTNPC1RAB9AHPGD | |
| SCHEMBL3438262 | 0.84 | EGFR (0.72) | EGFRMAPTNPC1RAB9AHPGD | |
| SCHEMBL28010587 | 0.84 | MAPT (0.58) | EGFRMAPTNPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102557969-B | Cyclic ketone derivatives and applications thereof as developers and aggregation inhibitors of amyloid protein sediments and neurofibrillary tangles | USTC UNIV SCIENCE TECH CN | 2015-03-18 | — | — | CN | claimed |
| CN-102557969-B | Cyclic ketone derivatives and applications thereof as developers and aggregation inhibitors of amyloid protein sediments and neurofibrillary tangles | USTC UNIV SCIENCE TECH CN | 2015-03-18 | — | — | CN | disclosed |