Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.68 |
| ▸ | NPC1 | O15118 | 3/20 | 0.68 |
| ▸ | RAB9A | P51151 | 3/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | EGFR | P00533 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | MAOA | P21397 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.49 |
| ▸ | CLK1 | P49759 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28010677 | 0.86 | EGFR (0.58) | MAPTNPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL809541 | 0.85 | CYP1A2 (0.78) | MAPTNPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL1524447 | 0.85 | CYP1A2 (0.78) | MAPTNPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL3738691 | 0.85 | MAPT (0.93) | MAPTNPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL10621315 | 0.85 | MAPT (0.93) | MAPTNPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL812347 | 0.85 | CYP1A2 (0.78) | MAPTNPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL10021997 | 0.85 | MAPT (0.93) | MAPTNPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL28009927 | 0.85 | MAPT (0.72) | MAPTNPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL28009938 | 0.85 | MAPT (0.72) | MAPTNPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL4576499 | 0.82 | MAPT (1.00) | MAPTNPC1RAB9AHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102557969-B | Cyclic ketone derivatives and applications thereof as developers and aggregation inhibitors of amyloid protein sediments and neurofibrillary tangles | USTC UNIV SCIENCE TECH CN | 2015-03-18 | — | — | CN | claimed |
| CN-102557969-B | Cyclic ketone derivatives and applications thereof as developers and aggregation inhibitors of amyloid protein sediments and neurofibrillary tangles | USTC UNIV SCIENCE TECH CN | 2015-03-18 | — | — | CN | disclosed |