Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.60 |
| ▸ | CA2 | P00918 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Catechol SCHEMBL28023341 | 0.84 | CA1 (0.49) | CA1CA2TSHRMAPTKMT2A | |
| Guaiacol SCHEMBL4089861 | 0.82 | CA1 (0.69) | TP53CA1CA2TSHRMAPT | |
| Guaiacol SCHEMBL21542 | 0.82 | CA1 (0.82) | TP53CA1CA2TSHRMAPT | |
| Guaiacol SCHEMBL5665553 | 0.80 | CA1 (0.78) | TP53CA1CA2TSHRMAPT | |
| Guaiacol SCHEMBL27509885 | 0.80 | CA1 (0.86) | TP53CA1CA2TSHRMAPT | |
| Guaiacol SCHEMBL28330363 | 0.80 | CA1 (0.86) | TP53CA1CA2TSHRMAPT | |
| Guaiacol SCHEMBL11574553 | 0.80 | CA1 (0.95) | TP53CA1CA2TSHRMAPT | |
| Guaiacol SCHEMBL27937887 | 0.80 | CA1 (0.95) | TP53CA1CA2TSHRMAPT | |
| Guaiacol SCHEMBL3361883 | 0.79 | CA1 (0.69) | TP53CA1CA2TSHRMAPT | |
| Guaiacol SCHEMBL27262483 | 0.79 | TP53 (0.69) | TP53CA1CA2TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104583196-B | The method that 1,4-dibasic pyridazine analog and treatment lack relevant disease to SMN | 诺华股份有限公司 | 2016-10-12 | — | — | CN | disclosed |
| CN-104583196-A | 1,4-disubstituted pyridazine analogs and methods for treating SMN-deficiency-related conditions | NOVARTIS AG | 2015-04-29 | — | — | CN | disclosed |