Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Guaiacol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.82 |
| ▸ | CA2 | P00918 | 3/20 | 0.82 |
| ▸ | TP53 | P04637 | 2/20 | 0.82 |
| ▸ | TSHR | P16473 | 2/20 | 0.82 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 2/20 | 0.54 |
| ▸ | CA7 | P43166 | 2/20 | 0.54 |
| ▸ | CA9 | Q16790 | 2/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guaiacol SCHEMBL5665553 | 0.93 | CA1 (0.78) | CA1CA2TP53TSHRMAPT | |
| Guaiacol SCHEMBL11574553 | 0.93 | CA1 (0.95) | CA1CA2TP53TSHRMAPT | |
| Guaiacol SCHEMBL27937887 | 0.93 | CA1 (0.95) | CA1CA2TP53TSHRMAPT | |
| Guaiacol SCHEMBL5176489 | 0.92 | CA1 (0.69) | CA1CA2TP53TSHRMAPT | |
| Guaiacol SCHEMBL10856965 | 0.91 | CA1 (0.75) | CA1CA2TP53TSHRMAPT | |
| Guaiacol SCHEMBL28032481 | 0.91 | CA1 (0.82) | CA1CA2TP53TSHRMAPT | |
| Guaiacol SCHEMBL671733 | 0.91 | CA2 (1.00) | CA1CA2TP53TSHRMAPT | |
| Guaiacol SCHEMBL29454477 | 0.91 | — | — | |
| Guaiacol SCHEMBL21626 | 0.91 | — | — | |
| Guaiacol SCHEMBL7134809 | 0.88 | CA1 (0.86) | CA1CA2TP53TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 283 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117024846-A | Method for degrading polycarbonate by using phenol catalyst | 中国科学院青岛生物能源与过程研究所 | 2023-11-10 | — | — | CN | claimed |
| CN-109988296-B | Process for producing polycarbonate polyol and polycarbonate polyol composition | 财团法人工业技术研究院 | 2021-09-10 | — | — | CN | claimed |
| WO-2021054927-A2 | GLUTATHIONE-CHOLESTEROL DERIVATIVES AS BRAIN TARGETING AGENTS | SOUTH DAKOTA BOARD OF REGENTS (US) | 2021-03-25 | — | — | WO | claimed |
| US-10689488-B2 | Method for preparing polycarbonate polyol and composition comprising the polycarbonate polyol | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2020-06-23 | — | — | US | claimed |
| CN-111138406-A | Sulfonium sulfonate photo-acid generator synthesized from guaiol and synthesis method thereof | 上海博栋化学科技有限公司 | 2020-05-12 | — | — | CN | claimed |
| US-20200048305-A1 | GLUTATHIONE-CHOLESTEROL DERIVATIVES AS BRAIN TARGETING AGENTS | SOUTH DAKOTA BOARD OF REGENTS (US) | 2020-02-13 | — | — | US | claimed |
| US-20190202981-A1 | METHOD FOR PREPARING POLYCARBONATE POLYOL AND COMPOSITION COMPRISING THE POLYCARBONATE POLYOL | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2019-07-04 | — | — | US | claimed |
| US-9622969-B2 | Polymer conjugated protein micelles | SOUTH DAKOTA STATE UNIV (US) | 2017-04-18 | — | — | US | claimed |
| US-20140370110-A1 | POLYMER CONJUGATED PROTEIN MICELLES | SOUTH DAKOTA STATE UNIVERSITY (US) | 2014-12-18 | — | — | US | claimed |
| EP-2729136-A1 | DRUG COMBINATIONS AND USES IN TREATING A COUGHING CONDITION | Biocopea Limited (GB) | 2014-05-14 | — | — | EP | claimed |
| CN-103648488-A | Pharmaceutical compositions and use in treating cough conditions | BIOCOPEA LTD | 2014-03-19 | — | — | CN | claimed |
| EP-2608847-A1 | THEOBROMINE IN COMBINATION WITH AN EXPECTORANT OR A MUCOLYTIC FOR USE IN THERAPY | Biocopea Limited (GB) | 2013-07-03 | — | — | EP | claimed |
| WO-2013004999-A1 | DRUG COMBINATIONS AND USES IN TREATING A COUGHING CONDITION | BIOCOPEA LIMITED (GB) | 2013-01-10 | — | — | WO | claimed |
| WO-2012025761-A1 | THEOBROMINE IN COMBINATION WITH AN EXPECTORANT OR A MUCOLYTIC FOR USE IN THERAPY | BIOCOPEA LIMITED (GB) | 2012-03-01 | — | — | WO | claimed |
| EP-4519340-B1 | PROCESS FOR PREPARING A POLYCARBONATE BY METAL CATALYZED CROSS COUPLING | COVESTRO DEUTSCHLAND AG (DE) | 2026-04-01 | — | — | EP | disclosed |
| EP-4022391-B1 | HEAT SENSITIVE RECORDING MATERIAL WITH NON-PHENOLIC COLOR DEVELOPERS | SOLENIS TECHNOLOGIES CAYMAN LP (KY) | 2026-03-04 | — | — | EP | disclosed |
| EP-4463503-B1 | PROCESS FOR PREPARING POLYCARBONATE BY BLANC-TYPE METHYLATION | COVESTRO DEUTSCHLAND AG (DE) | 2025-12-24 | — | — | EP | disclosed |
| US-5306687-A | Optical recording media comprising p'-methylphenyl p-chlorobenzoate as thermosensitizers | RICOH COMPANY, LTD. (JP) | 1994-04-26 | — | — | US | disclosed |
| EP-0055313-A1 | Guaiacol and derivatives; compositions thereof and use in a method of treatment | ED. GEISTLICH SÖHNE AG FÜR CHEMISCHE INDUSTRIE (CH) | 1982-07-07 | — | — | EP | disclosed |
| US-938132-A | GUAIACOL CARBONATE SULFO-ACID DERIVATIVE. | BOEHRINGER SOHN INGELHEIM (DE) | 1909-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048305-A1 | GLUTATHIONE-CHOLESTEROL DERIVATIVES AS BRAIN TARGETING AGENTS | GSTK1, GSTO1, GSTM2 | CA1 725/4885CA2 2428/4885TP53 4095/4885 |
| US-20140370110-A1 | POLYMER CONJUGATED PROTEIN MICELLES | MTDH, PSMG3, GHITM | CA1 3087/4885CA2 4462/4885TP53 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.