Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | UGCG | Q16739 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2801198 | 1.00 | MAPT (0.46) | MAPTLMNAALDH1A1TACR1SMN1; SMN2 | |
| SCHEMBL2800375 | 0.87 | TACR1 (0.56) | TACR1HSD17B10CHRM1UGCG | |
| SCHEMBL2800372 | 0.87 | TACR1 (0.56) | TACR1HSD17B10CHRM1UGCG | |
| SCHEMBL13198394 | 0.86 | MAPT (0.42) | MAPTLMNAALDH1A1TACR1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3791647 | 0.79 | UGCG (0.50) | LMNATACR1SMN1; SMN2GAANPSR1 | |
| Hydrochloric Acid SCHEMBL3791640 | 0.79 | UGCG (0.50) | LMNATACR1SMN1; SMN2GAANPSR1 | |
| SCHEMBL2545138 | 0.76 | TSHR (0.57) | MAPTALDH1A1TACR1SMN1; SMN2GAA | |
| Hydrochloric Acid SCHEMBL2545139 | 0.75 | TSHR (0.56) | MAPTLMNAALDH1A1TACR1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2545135 | 0.75 | TSHR (0.56) | MAPTLMNAALDH1A1TACR1SMN1; SMN2 | |
| SCHEMBL2032174 | 0.73 | GRM5 (0.62) | MAPTLMNAALDH1A1TACR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010091104-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | EXELIXIS, INC. (US) | 2010-08-12 | — | — | WO | disclosed |