Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 12/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | MPI | P34949 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7544923 | 0.79 | CASR (0.64) | CASRDDAH1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL30731281 | 0.75 | CASR (0.55) | CASRDDAH1NPC1RAB9AFBP1 | |
| SCHEMBL227210 | 0.74 | CASR (0.58) | CASRALDH1A1LMNAL3MBTL1TDP1 | |
| SCHEMBL108180 | 0.74 | CASR (0.58) | CASRALDH1A1LMNAL3MBTL1TDP1 | |
| SCHEMBL30731332 | 0.73 | CASR (0.57) | CASRALDH1A1LMNAL3MBTL1NPC1 | |
| SCHEMBL14859716 | 0.73 | CASR (0.50) | CASRTHRBRECQLALDH1A1LMNA | |
| SCHEMBL5720317 | 0.72 | CASR (0.51) | CASRALDH1A1L3MBTL1TDP1NPC1 | |
| SCHEMBL13890878 | 0.71 | CASR (0.51) | CASRALDH1A1LMNAL3MBTL1TDP1 | |
| SCHEMBL9037002 | 0.71 | THRB (0.51) | CASRTHRBRECQLALDH1A1LMNA | |
| SCHEMBL9052764 | 0.71 | CASR (0.51) | CASRALDH1A1LMNAL3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104640850-A | 3,4-disubstituted 1 H-pyrazole and 4,5-disubstituted thiazole inhibitors of SYK | HOFFMANN LA ROCHE | 2015-05-20 | — | — | CN | disclosed |