Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
| ▸ | PARP1 | P09874 | 5/20 | 0.57 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.55 |
| ▸ | KDM1A | O60341 | 6/20 | 0.50 |
| ▸ | MAOA | P21397 | 4/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.50 |
| ▸ | ITGAV | P06756 | 1/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.50 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.50 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2801393 | 1.00 | HRH3 (0.57) | HRH3PARP1PARP10KDM1AMAOA | |
| SCHEMBL13196796 | 1.00 | HRH3 (0.57) | HRH3PARP1PARP10KDM1AMAOA | |
| SCHEMBL13070743 | 0.81 | PARP1 (0.58) | HRH3PARP1KDM1AMAOAMAOB | |
| SCHEMBL6901368 | 0.81 | FFAR1 (0.49) | KDM1AMAOAMAOBITGB3ITGB1 | |
| SCHEMBL6901364 | 0.81 | FFAR1 (0.49) | KDM1AMAOAMAOBITGB3ITGB1 | |
| SCHEMBL2332584 | 0.81 | FFAR1 (0.56) | HRH3PARP1KDM1AMAOAITGB3 | |
| SCHEMBL2238222 | 0.81 | FFAR1 (0.56) | HRH3PARP1KDM1AMAOAITGB3 | |
| SCHEMBL2238225 | 0.81 | FFAR1 (0.56) | HRH3PARP1KDM1AMAOAITGB3 | |
| SCHEMBL24890703 | 0.80 | DGAT2 (0.52) | KDM1AMAOAITGB3ITGB1ITGAV | |
| SCHEMBL21501062 | 0.80 | DGAT2 (0.52) | KDM1AMAOAITGB3ITGB1ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150164889-A1 | CYCLOPROPYL AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2015-06-18 | — | — | US | disclosed |
| US-20150164888-A1 | CYCLOPROPYL AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2015-06-18 | — | — | US | disclosed |
| US-8993577-B2 | Cyclopropyl amide derivatives | ASTRAZENECA AB (SE) | 2015-03-31 | — | — | US | disclosed |
| CN-104398516-A | CYCLOPROPYL AMIDE DERIVATIVES TARGETING THE HISTAMINE H3 RECEPTOR | ASTRAZENECA AB | 2015-03-11 | — | — | CN | disclosed |
| CN-102405213-B | Cyclopropyl amide derivatives targeting histamine H3 receptor | ASTRAZENECA SWEDEN AB | 2014-11-19 | — | — | CN | disclosed |
| EP-2398780-B1 | CYCLOPROPYL AMIDE DERIVATIVES TARGETING THE HISTAMINE H3 RECEPTOR | ASTRAZENECA AB (SE) | 2013-04-17 | — | — | EP | disclosed |
| CN-102405213-A | Cyclopropyl amide derivatives targeting histamine H3 receptor | ASTRAZENECA AB | 2012-04-04 | — | — | CN | disclosed |
| EP-2398780-A1 | CYCLOPROPYL AMIDE DERIVATIVES TARGETING THE HISTAMINE H3 RECEPTOR | AstraZeneca AB (SE) | 2011-12-28 | — | — | EP | disclosed |
| US-20100216812-A1 | Cyclopropyl Amide Derivatives | ASTRAZENECA AB (SE) | 2010-08-26 | — | — | US | disclosed |
| WO-2010096011-A1 | CYCLOPROPYL AMIDE DERIVATIVES TARGETING THE HISTAMINE H3 RECEPTOR | ASTRAZENECA AB (SE) | 2010-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216812-A1 | Cyclopropyl Amide Derivatives | HRH4, HRH2, HRH3 | HRH3 3/4885PARP1 2062/4885PARP10 990/4885 |
| US-20150164888-A1 | CYCLOPROPYL AMIDE DERIVATIVES | HRH4, HRH2, HRH3 | HRH3 3/4885PARP1 2062/4885PARP10 990/4885 |
| US-20150164889-A1 | CYCLOPROPYL AMIDE DERIVATIVES | HRH4, HRH2, HRH3 | HRH3 3/4885PARP1 2062/4885PARP10 990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.