Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UNG | P13051 | 1/20 | 0.61 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.45 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | P4HB | P07237 | 2/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28770770 | 0.84 | UNG (0.42) | UNGALDH1A1POLBP4HBGRIN2D | |
| SCHEMBL27985856 | 0.81 | UNG (0.61) | UNGTRIM24TRIM33ALDH1A1POLB | |
| SCHEMBL47068 | 0.81 | ALDH1A1 (0.61) | UNGALDH1A1POLBP4HBGRIN2D | |
| SCHEMBL29677467 | 0.81 | ALDH1A1 (0.61) | UNGALDH1A1POLBP4HBGRIN2D | |
| SCHEMBL28346784 | 0.81 | UNG (0.61) | UNGTRIM24TRIM33ALDH1A1POLB | |
| SCHEMBL2514444 | 0.81 | UNG (0.56) | UNGTRIM24TRIM33ALDH1A1POLB | |
| SCHEMBL13521535 | 0.80 | UNG (0.59) | UNGTRIM24TRIM33ALDH1A1POLB | |
| SCHEMBL6853599 | 0.78 | UNG (0.73) | UNGTRIM24TRIM33ALDH1A1SRC | |
| SCHEMBL2223288 | 0.77 | SMN1; SMN2 (0.57) | UNGTRIM24TRIM33ALDH1A1POLB | |
| SCHEMBL97218 | 0.77 | POLB (0.57) | UNGALDH1A1POLBNPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105085407-A | Preparation method of Olaparib and analogue of Olaparib | GUANGZHOU YOUMIJIAN PHARMACEUTICAL TECHNOLOGY CO LTD | 2015-11-25 | — | — | CN | claimed |
| CN-105085408-A | Preparation method of Olaparib intermediate | GUANGZHOU YOUMIJIAN PHARMACEUTICAL TECHNOLOGY CO LTD | 2015-11-25 | — | — | CN | claimed |
| CN-109232575-A | Pyrroles's [1,2-b] pyridazine compound or its officinal salt and their purposes | 中国科学院上海药物研究所 | 2019-01-18 | — | — | CN | disclosed |
| CN-108191769-A | A kind of preparation method of olaparib | 山东裕欣药业有限公司 | 2018-06-22 | — | — | CN | disclosed |
| CN-108101852-A | A kind of preparation method of olaparib | 山东裕欣药业有限公司 | 2018-06-01 | — | — | CN | disclosed |
| CN-107325055-A | A kind of synthetic method of olaparib compound | 山东裕欣药业有限公司 | 2017-11-07 | — | — | CN | disclosed |
| CN-104114555-B | Pyrazolopyrimidine derivatives, process for their preparation and their therapeutic use | 赛诺菲 | 2017-09-01 | — | — | CN | disclosed |
| CN-106573915-A | Compounds active against bromodomains | 纽韦卢森公司 | 2017-04-19 | — | — | CN | disclosed |
| CN-104478875-B | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) | 麦迪韦逊科技有限公司 | 2017-04-12 | — | — | CN | disclosed |
| CN-102834397-B | Macrocyclic compounds as factor XIA inhibitors | BRISTOL-MYERS SQUIBB CO. (US) | 2016-02-03 | — | — | CN | disclosed |
| CN-105085407-A | Preparation method of Olaparib and analogue of Olaparib | GUANGZHOU YOUMIJIAN PHARMACEUTICAL TECHNOLOGY CO LTD | 2015-11-25 | — | — | CN | disclosed |
| CN-105085408-A | Preparation method of Olaparib intermediate | GUANGZHOU YOUMIJIAN PHARMACEUTICAL TECHNOLOGY CO LTD | 2015-11-25 | — | — | CN | disclosed |
| CN-104744305-A | Synthesis method of 2,4-dichloro-3-cyan-5-fluorobenzoic acid | ZHEJIANG ZHONGXIN CHEMICALS CO LTD | 2015-07-01 | — | — | CN | disclosed |
| CN-102171214-B | Dihydropyridophthalazinone inhibitors of poly (ADP-ribose) polymerase (PARP) | BIOMARIN PHARM INC | 2015-06-24 | — | — | CN | disclosed |
| CN-104478875-A | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) | BIOMARIN PHARM INC | 2015-04-01 | — | — | CN | disclosed |