Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.53 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.46 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL361288 | 0.96 | ESR1 (0.53) | ESR1ESR2ACMSDMAPTTDP1 | |
| SCHEMBL237166 | 0.96 | ESR1 (0.57) | ESR1ESR2ACMSDMAPTTDP1 | |
| SCHEMBL236488 | 0.96 | ESR1 (0.57) | ESR1ESR2ACMSDMAPTTDP1 | |
| SCHEMBL29672387 | 0.96 | ESR1 (0.57) | ESR1ESR2ACMSDMAPTTDP1 | |
| SCHEMBL25274668 | 0.87 | ESR1 (0.55) | ESR1ESR2ACMSDMAPTTDP1 | |
| Bicarbonate SCHEMBL27850310 | 0.85 | ESR1 (0.65) | ESR1ESR2ACMSDALOX5CA1 | |
| Bicarbonate SCHEMBL27837040 | 0.85 | ESR1 (0.65) | ESR1ESR2ACMSDALOX5CA1 | |
| SCHEMBL1808182 | 0.83 | KMT2A (0.65) | MAPTTDP1MEN1KMT2APTPN7 | |
| SCHEMBL21790492 | 0.82 | KMT2A (0.50) | MAPTTDP1MEN1KMT2ALMNA | |
| SCHEMBL233643 | 0.82 | KMT2A (0.55) | MAPTTDP1MEN1KMT2ACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105714282-A | Method and apparatus for producing polycarbonate | 拜尔材料科学股份公司 | 2016-06-29 | — | — | CN | disclosed |
| CN-102102204-B | Method and apparatus for producing polycarbonate | BAYER MATERIALSCIENCE AG (DE) | 2016-04-27 | — | — | CN | disclosed |
| CN-105189445-A | Purification method of diphenyl carbonate for preparing high quality polycarbonate | SABIC INNOVATIVE PLASTICS IP | 2015-12-23 | — | — | CN | disclosed |
| CN-104640837-A | Process for the continuous manufacture of aryl alkyl carbonate and/or diaryl carbonate using vapor recompression | SABIC INNOVATIVE PLASTICS IP | 2015-05-20 | — | — | CN | disclosed |