Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.46 |
| ▸ | HBB | P68871 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PI4KA | P42356 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | NNMT | P40261 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5108 | 0.84 | ALDH1A1 (0.49) | KDM4EMEN1KMT2AALDH1A1BRCA1 | |
| SCHEMBL28290759 | 0.81 | KDM4E (0.46) | KDM4EMEN1KMT2AALDH1A1BRCA1 | |
| SCHEMBL21312156 | 0.81 | KDM4E (0.47) | KDM4EMEN1KMT2AALDH1A1BRCA1 | |
| SCHEMBL113293 | 0.77 | — | — | |
| SCHEMBL29536663 | 0.77 | — | — | |
| SCHEMBL4763804 | 0.77 | ALDH1A1 (0.36) | KDM4EMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL11289 | 0.77 | KDM4E (0.44) | KDM4EMEN1KMT2AALDH1A1BRCA1 | |
| SCHEMBL10363 | 0.77 | KDM4E (0.44) | KDM4EMEN1KMT2AALDH1A1BRCA1 | |
| SCHEMBL743471 | 0.77 | KDM4E (0.44) | KDM4EMEN1KMT2AALDH1A1BRCA1 | |
| SCHEMBL2645686 | 0.76 | ALOX5AP (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104761544-A | Selectivity inhibitor of EGFR tyrosine kinase clinic important mutant | CS THERAPEUTICS INC | 2015-07-08 | — | — | CN | disclosed |