Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.35 |
| ▸ | CTSA | P10619 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21043609 | 0.85 | CHEK1 (0.43) | AKR1C2AKR1C1AURKATPX2PIM1 | |
| SCHEMBL17128715 | 0.80 | ESR2 (0.36) | AURKAPIM1PIM2MMP13CHEK1 | |
| SCHEMBL2468746 | 0.79 | EGLN1 (0.48) | — | |
| SCHEMBL28019089 | 0.79 | HPGD (0.36) | AKR1C2ESR1CTSASCN9A | |
| SCHEMBL2472274 | 0.75 | PIM2 (0.42) | AKR1C2AKR1C1AURKATPX2PIM1 | |
| SCHEMBL28019080 | 0.71 | ESR1 (0.37) | AKR1C2ESR1DHODHCTSASCN9A | |
| SCHEMBL2470341 | 0.70 | L3MBTL1 (0.58) | HDAC6 | |
| SCHEMBL2471654 | 0.68 | L3MBTL1 (0.43) | DHODH | |
| SCHEMBL2475738 | 0.65 | KDM4E (0.53) | — | |
| SCHEMBL2469965 | 0.63 | RPS6KB1 (0.46) | PIM1PIM2DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105037323-A | Thiochromene derivatives as HIF hydroxylase inhibitors | FIBROGEN INC | 2015-11-11 | — | — | CN | claimed |
| CN-105037323-A | Thiochromene derivatives as HIF hydroxylase inhibitors | FIBROGEN INC | 2015-11-11 | — | — | CN | disclosed |
| CN-102272117-B | Benzothiopyran derivatives as HIF hydroxylase inhibitors | FIBROGEN INC | 2015-06-17 | — | — | CN | disclosed |