Pyrazine

Pyrazine

SCHEMBL28019686

COC(C)OCc1cnccn1.c1cnccn1

nearest known ligand 0.37

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PSMB5 P28074 1/20 0.37
SYK P43405 3/20 0.34
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
ATM Q13315 1/20 0.32
BIRC5 O15392 1/20 0.31
RIPK2 O43353 1/20 0.31
SP1 P08047 1/20 0.31
ILF3 Q12906 1/20 0.31
PAK1 Q13153 1/20 0.31
GABRA1 P14867 1/20 0.30
GABRG2 P18507 1/20 0.30
GABRB3 P28472 1/20 0.30
GABRA5 P31644 1/20 0.30
GABRA3 P34903 1/20 0.30
GABRA2 P47869 1/20 0.30
ACACB O00763 1/20 0.30
CYP1A2 P05177 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28019751 0.98 PSMB5 (0.38) PSMB5SYKKDM4EALDH1A1SMN1; SMN2
SCHEMBL28020188 0.92 PSMB5 (0.35) PSMB5SYKKDM4EALDH1A1SMN1; SMN2
SCHEMBL10849052 0.82 PSMB5 (0.40) PSMB5SYKKDM4EALDH1A1SMN1; SMN2
SCHEMBL570248 0.75
SCHEMBL31415045 0.75
SCHEMBL28035933 0.74 SYK (0.43) SYKKDM4EALDH1A1SMN1; SMN2GABRA1
SCHEMBL2608842 0.71 KDM4E (0.37) PSMB5SYKKDM4EALDH1A1SMN1; SMN2
SCHEMBL27635497 0.71 NLRP3 (0.36) SYKKDM4EALDH1A1SMN1; SMN2ATM
SCHEMBL28035934 0.70 SYK (0.40) SYKKDM4EALDH1A1SMN1; SMN2GABRA1
SCHEMBL5569539 0.68 GRM5 (0.36) SYKKDM4ESMN1; SMN2GABRA1GABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102952098-B Pyrazine ionic liquid and its preparation method and application Haiyangwang Lighting Technology Co., Ltd. (CN) 2015-08-05 CN disclosed