Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.61 |
| ▸ | ACVR1 | Q04771 | 8/20 | 0.53 |
| ▸ | AKT1 | P31749 | 2/20 | 0.48 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.45 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.44 |
| ▸ | CCNK | O75909 | 1/20 | 0.44 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL730195 | 0.84 | PIK3CA (0.84) | PIK3CAACVR1AKT1 | |
| SCHEMBL9709110 | 0.82 | PIK3CA (0.87) | PIK3CAACVR1AKT1CAMKK1CAMKK2 | |
| SCHEMBL730188 | 0.82 | PIK3CA (0.87) | PIK3CAACVR1AKT1DYRK1B | |
| SCHEMBL30440111 | 0.81 | PIK3CA (0.64) | PIK3CAACVR1AKT1 | |
| SCHEMBL529894 | 0.81 | PIK3CA (0.64) | PIK3CAACVR1AKT1CAMKK1CAMKK2 | |
| SCHEMBL28175732 | 0.78 | PIK3CA (0.53) | PIK3CAACVR1AKT1TLR8KDM4E | |
| SCHEMBL729963 | 0.76 | PIK3CA (0.64) | PIK3CAACVR1AKT1 | |
| SCHEMBL731426 | 0.76 | PIK3CA (0.64) | PIK3CAACVR1AKT1DYRK1B | |
| SCHEMBL731969 | 0.75 | PIK3CA (0.70) | PIK3CAAKT1 | |
| SCHEMBL729836 | 0.75 | PIK3CA (0.74) | PIK3CAAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103402997-B | Diaminopyrimidine derivatives and process for preparing same | Liu Hanyangxing (KR) | 2015-08-26 | — | — | CN | disclosed |