Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL602641 | 0.74 | HRH3 (0.51) | ADRB1HRH3HRH4 | |
| SCHEMBL9883827 | 0.74 | HRH3 (0.51) | ADRB1HRH3HRH4 | |
| SCHEMBL2569183 | 0.71 | BPTF (0.36) | ADRB1 | |
| SCHEMBL605194 | 0.70 | HRH3 (0.45) | ADRB1HRH3HRH4 | |
| SCHEMBL601894 | 0.68 | ADRB1 (0.44) | ADRB1HRH3HRH4 | |
| Trifluoroacetic Acid SCHEMBL9104338 | 0.68 | HRH3 (0.43) | ADRB1HRH3HRH4 | |
| SCHEMBL9883822 | 0.67 | ADRB1 (0.37) | ADRB1HRH4 | |
| SCHEMBL9883821 | 0.67 | ADRB1 (0.37) | ADRB1HRH4 | |
| SCHEMBL604915 | 0.65 | ADRB1 (0.49) | ADRB1KMT2AHRH4 | |
| SCHEMBL604445 | 0.65 | PRKCI (0.45) | ADRB1HRH3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200595-A2 | THIENO-AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | Janssen Pharmaceutica, N.V. (BE) | 2010-06-30 | — | — | EP | claimed |
| WO-2009038673-A2 | THIENO-AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-26 | — | — | WO | claimed |