Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.44 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.44 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.44 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL341835 | 0.78 | KDM4E (1.00) | KDM4EMAPK1HPGDMEN1TRPM2 | |
| SCHEMBL2412888 | 0.77 | KDM4E (0.96) | KDM4EMAPK1HPGDMEN1TRPM2 | |
| SCHEMBL28480364 | 0.76 | KDM4E (0.46) | KDM4EMAPK1HPGDMEN1TRPM2 | |
| SCHEMBL2410144 | 0.73 | KDM4E (0.88) | KDM4EMAPK1HPGDMEN1TRPM2 | |
| SCHEMBL12270752 | 0.73 | KDM4E (0.81) | KDM4EMAPK1HPGDMEN1TRPM2 | |
| SCHEMBL93572 | 0.72 | TAAR1 (0.50) | KDM4EMAPK1HPGDMEN1TRPM2 | |
| SCHEMBL2409329 | 0.72 | KDM4E (0.85) | KDM4EMAPK1HPGDMEN1TRPM2 | |
| SCHEMBL12266145 | 0.69 | CYP1A2 (0.79) | KDM4EMAPK1HPGDMEN1TRPM2 | |
| SCHEMBL14198827 | 0.69 | KDM4E (0.79) | KDM4EMAPK1HPGDMEN1TRPM2 | |
| SCHEMBL12266286 | 0.69 | KDM4E (0.72) | KDM4EMAPK1HPGDMEN1TRPM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113692304-A | 1- ((2- (2,2, 2-trifluoroethoxy) pyridin-4-yl) methyl) urea derivatives as KCNQ enhancers | 礼来公司 | 2021-11-23 | — | — | CN | disclosed |
| CN-104203256-B | Therapeutic alliance for the glucosaminoglycan comprising sulphation of induced labor | 迪乐方有限责任公司 | 2017-11-24 | — | — | CN | disclosed |
| CN-104244957-B | The method stopped for treating childbirth | 迪乐方有限责任公司 | 2017-11-17 | — | — | CN | disclosed |
| CN-105579044-A | Use of dianhydrogalactitol and analogs and derivatives thereof for treating recurrent malignant glioma or progressive secondary brain tumor | DEL MAR PHARMACEUTICALS | 2016-05-11 | — | — | CN | disclosed |
| CN-105492011-A | Therapeutic synergy of undesirable chemical compounds | BROWN DENNIS M | 2016-04-13 | — | — | CN | disclosed |
| CN-104797267-A | Method of treating tyrosine kinase inhibitor-resistant malignancies in patients with genetic polymorphism or AHI1 dysregulation or mutation using dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof | DEL MAR PHARMACEUTICALS | 2015-07-22 | — | — | CN | disclosed |