Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 4/20 | 0.64 |
| ▸ | BRAF | P15056 | 12/20 | 0.52 |
| ▸ | CSF1R | P07333 | 3/20 | 0.51 |
| ▸ | KIT | P10721 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | BMX | P51813 | 1/20 | 0.45 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | LYN | P07948 | 1/20 | 0.45 |
| ▸ | HCK | P08631 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | TEK | Q02763 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL374496 | 0.87 | LCK (0.67) | LCKBRAFCSF1RKITKDR | |
| SCHEMBL374728 | 0.83 | LCK (0.65) | LCKBRAFCSF1RKITKDR | |
| SCHEMBL374545 | 0.82 | LCK (0.68) | LCKBRAFCSF1RKITKDR | |
| SCHEMBL374503 | 0.82 | LCK (0.67) | LCKBRAFCSF1RKITKDR | |
| SCHEMBL374492 | 0.81 | LCK (0.70) | LCKBRAFCSF1RKITKDR | |
| SCHEMBL379539 | 0.81 | LCK (0.59) | LCKBRAFCSF1RKITKDR | |
| SCHEMBL374499 | 0.79 | LCK (0.76) | LCKBRAFCSF1RKITKDR | |
| SCHEMBL373967 | 0.79 | LCK (0.64) | LCKBRAFCSF1RKITKDR | |
| SCHEMBL374341 | 0.79 | LCK (0.67) | LCKBRAFCSF1RKITKDR | |
| SCHEMBL374410 | 0.78 | LCK (0.66) | LCKBRAFCSF1RKITKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103121972-B | As the pyrimidine urea derivatives of kinase inhibitor | NOVARTIS AG (CH) | 2015-07-29 | — | — | CN | disclosed |