Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 7/20 | 0.50 |
| ▸ | EGFR | P00533 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ABL1 | P00519 | 3/20 | 0.50 |
| ▸ | KIT | P10721 | 3/20 | 0.50 |
| ▸ | SRC | P12931 | 3/20 | 0.50 |
| ▸ | BRAF | P15056 | 3/20 | 0.50 |
| ▸ | KDR | P35968 | 3/20 | 0.50 |
| ▸ | TEK | Q02763 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 7/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL373374 | 0.92 | FGFR3 (0.56) | FGFR1EGFRABL1KITSRC | |
| SCHEMBL28023618 | 0.92 | FGFR1 (0.59) | FGFR1EGFRRAB9ANPC1TP53 | |
| SCHEMBL28821018 | 0.88 | ABL1 (0.49) | FGFR1EGFRABL1KITSRC | |
| SCHEMBL374657 | 0.85 | FGFR3 (0.58) | FGFR1EGFRABL1KITSRC | |
| SCHEMBL374228 | 0.80 | LCK (0.57) | FGFR1EGFRABL1KITSRC | |
| SCHEMBL373147 | 0.78 | FGFR3 (0.73) | EGFRRAB9AFGFR3JAK2LCK | |
| SCHEMBL15295501 | 0.78 | FGFR3 (0.59) | FGFR1EGFRABL1KITSRC | |
| SCHEMBL374474 | 0.78 | METTL3 (0.47) | FGFR1EGFRRAB9ANPC1TP53 | |
| SCHEMBL374470 | 0.77 | FGFR3 (0.56) | FGFR1EGFRABL1KITSRC | |
| SCHEMBL374703 | 0.75 | FGFR3 (0.75) | FGFR1EGFRABL1KITSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103121972-B | As the pyrimidine urea derivatives of kinase inhibitor | NOVARTIS AG (CH) | 2015-07-29 | — | — | CN | claimed |