Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 19/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.52 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | PAK4 | O96013 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | FLT1 | P17948 | 1/20 | 0.52 |
| ▸ | LTK | P29376 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28024443 | 0.83 | AURKA (0.84) | AURKAAURKBRIPK1 | |
| SCHEMBL27995814 | 0.75 | AURKA (0.50) | AURKAAURKBGSK3BDAPK3JAK2 | |
| SCHEMBL4167474 | 0.74 | JAK2 (0.43) | AURKAAURKBGSK3BJAK2JAK3 | |
| SCHEMBL22917367 | 0.73 | IGF1R (0.60) | AURKAAURKBGSK3BDAPK3JAK2 | |
| SCHEMBL12430944 | 0.71 | AURKA (0.65) | AURKAAURKBIGF1RPIK3C3 | |
| SCHEMBL220647 | 0.69 | PAK4 (0.57) | AURKAAURKBGSK3BDAPK3JAK2 | |
| SCHEMBL21635755 | 0.68 | AURKA (0.60) | AURKAGSK3BPAK4IGF1RSRC | |
| SCHEMBL12510417 | 0.68 | IGF1R (0.55) | AURKAAURKBGSK3BIGF1RPIK3C3 | |
| SCHEMBL12430951 | 0.68 | AURKA (0.63) | AURKAAURKBGSK3BDAPK3JAK2 | |
| SCHEMBL12102888 | 0.68 | GSK3B (0.50) | AURKAAURKBGSK3BDAPK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104693188-A | Pyrimidine compound and synthesis method and application thereof | LIU QIANG | 2015-06-10 | — | — | CN | disclosed |