Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.60 |
| ▸ | AURKA | O14965 | 12/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.55 |
| ▸ | RET | P07949 | 5/20 | 0.55 |
| ▸ | GSK3A | P49840 | 2/20 | 0.55 |
| ▸ | GSK3B | P49841 | 2/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | PAK4 | O96013 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | FYN | P06241 | 1/20 | 0.55 |
| ▸ | CSF1R | P07333 | 1/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.55 |
| ▸ | FLT1 | P17948 | 1/20 | 0.55 |
| ▸ | LTK | P29376 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15956798 | 0.83 | IGF1R (0.79) | IGF1RRETGSK3AGSK3BAKT1 | |
| SCHEMBL22917452 | 0.83 | IGF1R (0.56) | IGF1RAURKAAURKBRETGSK3A | |
| SCHEMBL27995814 | 0.80 | AURKA (0.50) | IGF1RAURKAAURKBRETGSK3A | |
| SCHEMBL12430664 | 0.79 | AURKA (0.74) | AURKAAURKBGSK3AGSK3BPAK4 | |
| SCHEMBL31471748 | 0.79 | AURKA (0.74) | AURKAAURKBGSK3AGSK3BPAK4 | |
| SCHEMBL22917649 | 0.76 | IGF1R (0.50) | IGF1RAURKARETGSK3AGSK3B | |
| SCHEMBL12430944 | 0.74 | AURKA (0.65) | IGF1RAURKAAURKBPIK3C3 | |
| SCHEMBL28024022 | 0.73 | AURKA (0.58) | IGF1RAURKAAURKBRETGSK3A | |
| SCHEMBL21067407 | 0.73 | IGF1R (0.82) | IGF1RRETGSK3AGSK3BAKT1 | |
| SCHEMBL12430939 | 0.73 | AURKA (0.61) | IGF1RAURKAAURKBRETGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021016102-A1 | INHIBITORS OF TYROSINE KINASE | BRIDGENE BIOSCIENCES, INC. (US) | 2021-01-28 | — | — | WO | disclosed |