Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.56 |
| ▸ | CASP6 | P55212 | 1/20 | 0.54 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL360006 | 0.83 | PDGFRB (0.74) | PDGFRBPDGFRACASP6TLR8ALDH1A1 | |
| Hydrochloric Acid SCHEMBL16146746 | 0.82 | PDGFRB (0.72) | PDGFRBPDGFRACASP6TLR8ALDH1A1 | |
| SCHEMBL16146299 | 0.81 | CASP6 (0.51) | PDGFRBPDGFRACASP6TLR8ALDH1A1 | |
| SCHEMBL16146822 | 0.80 | CASP6 (0.50) | PDGFRBPDGFRACASP6TLR8ALDH1A1 | |
| Hydrochloric Acid SCHEMBL16146283 | 0.80 | CASP6 (0.50) | PDGFRBPDGFRACASP6TLR8ALDH1A1 | |
| SCHEMBL1807825 | 0.79 | TLR8 (0.59) | TLR8ALDH1A1HSD17B10KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL16146276 | 0.79 | CASP6 (0.49) | PDGFRBPDGFRACASP6TLR8ALDH1A1 | |
| SCHEMBL28251532 | 0.79 | PDGFRB (0.57) | PDGFRBPDGFRACASP6TLR8ALDH1A1 | |
| SCHEMBL357325 | 0.79 | IRAK4 (0.48) | PDGFRBPDGFRACASP6TLR8ALDH1A1 | |
| SCHEMBL3343309 | 0.77 | CASP6 (0.57) | PDGFRBPDGFRACASP6TLR8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106905234-B | A method of the synthesis chloro- 6- amino -7- ethoxyquinoline of linatinib intermediate 3- cyano -4- | 淮海工学院 | 2019-04-23 | — | — | CN | disclosed |
| CN-106905234-A | A kind of method for synthesizing the ethoxyquinoline of 6 amino of HKI-272 intermediate 3 cyano group, 4 chlorine 7 | 淮海工学院 | 2017-06-30 | — | — | CN | disclosed |
| CN-104774184-A | Alpha-cyano-alpha, beta-unsaturated amide compound and medical application thereof | UNIV CHINA PHARMA | 2015-07-15 | — | — | CN | disclosed |