Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10374739 | 0.82 | KDM4E (0.33) | ALDH1A1KMT2AGAAKDM4ELMNA | |
| SCHEMBL31298552 | 0.82 | — | — | |
| SCHEMBL15663179 | 0.66 | — | — | |
| SCHEMBL17146949 | 0.65 | HSD11B1 (0.48) | HCAR2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL20558279 | 0.63 | HSD11B1 (0.44) | MAPTALDH1A1MAPK1KMT2APOLB | |
| SCHEMBL26103302 | 0.63 | — | — | |
| SCHEMBL7688352 | 0.62 | HSD11B1 (0.39) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL21835188 | 0.61 | KCNA5 (0.34) | MAPTALDH1A1CHRM2CHRM4CHRM5 | |
| SCHEMBL22629246 | 0.61 | HSD11B1 (0.40) | MAPTALDH1A1MAPK1KMT2AHCAR2 | |
| SCHEMBL22629830 | 0.61 | HSD11B1 (0.40) | MAPTALDH1A1MAPK1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104892502-A | Aryl pyridine as aldosterone synthase inhibitors | NOVARTIS AG | 2015-09-09 | — | — | CN | disclosed |
| CN-102803217-B | Aryl pyridines as aldosterone synthase inhibitors | NOVARTIS AG | 2015-06-17 | — | — | CN | disclosed |