Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | NCF1 | P14598 | 7/20 | 0.44 |
| ▸ | APP | P05067 | 4/20 | 0.44 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.37 |
| ▸ | PI4KA | P42356 | 2/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2799408 | 0.90 | PIK3CD (0.44) | MAPTNCF1APPBACE1PIK3CD | |
| SCHEMBL2799518 | 0.85 | APP (0.48) | MAPTAPP | |
| SCHEMBL2800659 | 0.84 | APP (0.54) | MAPTAPP | |
| SCHEMBL2803139 | 0.80 | APP (0.60) | MAPTNCF1APPRAD51 | |
| SCHEMBL2802333 | 0.79 | CYP1B1 (0.44) | MAPTNCF1APPBACE1CYP1B1 | |
| SCHEMBL13196949 | 0.79 | MAPT (0.44) | MAPTAPPBACE1 | |
| SCHEMBL2800843 | 0.77 | APP (0.60) | MAPTNCF1APP | |
| SCHEMBL13196988 | 0.76 | APP (0.53) | MAPTAPP | |
| SCHEMBL10076373 | 0.76 | NCF1 (0.48) | MAPTNCF1APPPIK3CDPIK3CA | |
| SCHEMBL14908786 | 0.76 | NCF1 (0.57) | MAPTNCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100215579-A1 | PHEN-NAPHTHALENE AND PHEN-QUINOLINE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (PA) | 2010-08-26 | — | — | US | disclosed |
| EP-2144916-A1 | PHEN-NAPHTHALENE AND PHEN-QUINOLINE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | The Trustees of the University of Pennsylvania (US) | 2010-01-20 | — | — | EP | disclosed |
| WO-2008124812-A1 | PHEN-NAPHTHALENE AND PHEN-QUINOLINE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100215579-A1 | PHEN-NAPHTHALENE AND PHEN-QUINOLINE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | APP, PSEN1, PSEN2 | MAPT 6/4885NCF1 828/4885APP 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.