Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 6/20 | 0.49 |
| ▸ | TNKS | O95271 | 1/20 | 0.48 |
| ▸ | WNT3A | P56704 | 1/20 | 0.48 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.48 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | COMT | P21964 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28818932 | 0.83 | PIK3CA (0.41) | NPBWR1DGAT1KCNH2KIT | |
| SCHEMBL984971 | 0.80 | NPBWR1 (0.53) | NPBWR1TNKSWNT3ATNKS2DGAT1 | |
| SCHEMBL5914424 | 0.80 | KDM4C (0.49) | TNKSTNKS2SCN2AGSK3B | |
| SCHEMBL24075230 | 0.79 | KIT (0.45) | NPBWR1TNKSWNT3ATNKS2DGAT1 | |
| SCHEMBL24074354 | 0.78 | NPBWR1 (0.48) | NPBWR1TNKSWNT3ATNKS2DGAT1 | |
| SCHEMBL24075058 | 0.78 | TNKS (0.47) | NPBWR1TNKSWNT3ATNKS2DGAT1 | |
| SCHEMBL3237120 | 0.78 | TRPV1 (0.56) | NPBWR1TNKSWNT3ATNKS2DGAT1 | |
| SCHEMBL24074361 | 0.77 | TRPV1 (0.51) | NPBWR1TNKSWNT3ATNKS2DGAT1 | |
| SCHEMBL11352702 | 0.77 | NPC1 (0.52) | NPBWR1TNKSTNKS2SCN2ACCNB2 | |
| SCHEMBL6946824 | 0.76 | KIT (0.45) | CCNB2CDK1CCNB1GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104918940-A | Purine inhibitors of human phosphatidylinositol 3-kinase | MERCK SHARP & DOHME | 2015-09-16 | — | — | CN | disclosed |