Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.58 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16637689 | 0.80 | ROCK2 (0.59) | ROCK2RETROCK1IGF1RGSK3A | |
| SCHEMBL16637787 | 0.79 | ROCK2 (0.61) | ROCK2RETROCK1IGF1RGSK3A | |
| SCHEMBL16638040 | 0.73 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL16637786 | 0.70 | ROCK2 (0.50) | ROCK2RETROCK1IGF1RGSK3A | |
| SCHEMBL15639979 | 0.66 | RET (0.60) | ROCK2RETROCK1IGF1RMKNK1 | |
| SCHEMBL6788501 | 0.65 | HSF1 (0.71) | ROCK2RETROCK1IGF1RGSK3A | |
| SCHEMBL27979030 | 0.65 | MAPK1 (0.51) | ROCK2ROCK1GSK3BCLK4RAB9A | |
| SCHEMBL27596563 | 0.65 | ROCK2 (0.58) | ROCK2ROCK1PRKG1CLK4MKNK1 | |
| SCHEMBL6181034 | 0.64 | RET (1.00) | RETMKNK1EGFRKDR | |
| SCHEMBL13154702 | 0.64 | RET (0.72) | ROCK2RETROCK1IGF1RMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104903312-A | RHO KINASE INHIBITORS | KADMON CORP LLC | 2015-09-09 | — | — | CN | disclosed |