⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28311023 | 0.67 | — | — | |
| SCHEMBL11003248 | 0.67 | — | — | |
| SCHEMBL295379 | 0.67 | — | — | |
| SCHEMBL6281679 | 0.65 | — | — | |
| SCHEMBL8731406 | 0.63 | — | — | |
| SCHEMBL8731401 | 0.63 | — | — | |
| SCHEMBL31509547 | 0.63 | — | — | |
| SCHEMBL3141014 | 0.62 | — | — | |
| SCHEMBL5842002 | 0.60 | — | — | |
| SCHEMBL9902151 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817627-B1 | PROTEIN KINASE C INHIBITORS | LILLY CO ELI (US) | 2005-03-09 | — | — | EP | claimed |
| EP-1449529-A1 | Protein Kinase C Inhibitors | ELI LILLY AND COMPANY (US) | 2004-08-25 | — | — | EP | claimed |
| CN-1041308-C | Process for preparing substituted maleimides | HOFFMANN LA ROCHE (CH) | 1998-12-23 | — | — | CN | claimed |
| EP-0817627-A1 | PROTEIN KINASE C INHIBITORS | ELI LILLY AND COMPANY (US) | 1998-01-14 | — | — | EP | claimed |
| EP-0540956-B1 | Process for the manufacture of substituted maleimides | HOFFMANN LA ROCHE (CH) | 1997-09-03 | — | — | EP | claimed |
| WO-1995017182-A1 | PROTEIN KINASE C INHIBITORS | ELI LILLY AND COMPANY (US) | 1995-06-29 | — | — | WO | claimed |
| US-5399712-A | Protein kinase C inhibitor | HOFFMANN-LA ROCHE INC. (US) | 1995-03-21 | — | — | US | claimed |
| CN-1072409-A | The preparation method of the maleimide that replaces | HOFFMANN LA ROCHE (CH) | 1993-05-26 | — | — | CN | claimed |
| EP-0409617-A2 | Thiolactams, process for their preparation and use as biocides | ZENECA LIMITED (GB) | 1991-01-23 | — | — | EP | claimed |
| EP-0405264-A1 | Hydroxy-keto-azoles | BAYER AG (DE) | 1991-01-02 | — | — | EP | claimed |
| JP-6329672-A | — | — | None | — | — | JP | disclosed |
| JP-5221977-A | — | — | None | — | — | JP | disclosed |
| JP-3068553-A | — | — | None | — | — | JP | disclosed |
| US-7772159-B2 | Solution and solid phase synthesis of pyrrolinones and polypyrrolinones | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-08-10 | — | — | US | disclosed |
| WO-2007096764-A2 | BICYCLIC HETEROARYL DERIVATIVES AS CANNABINOID RECEPTOR MODULATORS | GLENMARK PHARMACEUTICALS S.A. (US) | 2007-08-30 | — | — | WO | disclosed |
| US-4897489-A | 2-/5-OXO-2-TETRAHYDROFURANY4-3-OXOISOXOL-IDINE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-01-30 | — | — | US | disclosed |
| US-4851422-A | Antibiotic 2-(3-oxo-2-isoxazolidinyl)-5-oxo-2-tetrahydrofuran-carboxylates | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-07-25 | — | — | US | disclosed |
| EP-0219923-A1 | Antibiotic derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1987-04-29 | — | — | EP | disclosed |
| CN-86102923-A | The method for preparing antibiotic derivatives | — | 1986-11-12 | — | — | CN | disclosed |
| EP-0191989-A1 | Antibiotic isoxazole derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1986-08-27 | — | — | EP | disclosed |