Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tert-Butyl Formate SCHEMBL28027171 | 0.85 | TDP1 (0.42) | TDP1 | |
| SCHEMBL1504410 | 0.78 | — | — | |
| Tert-Butyl Formate SCHEMBL22720790 | 0.77 | TDP1 (0.59) | TDP1 | |
| Tert-Butyl Formate SCHEMBL28297827 | 0.76 | TDP1 (0.43) | TDP1 | |
| Hydrochloric Acid SCHEMBL16007560 | 0.76 | — | — | |
| Tert-Butyl Formate SCHEMBL28092409 | 0.75 | TDP1 (0.56) | TDP1 | |
| Tert-Butyl Formate SCHEMBL28226550 | 0.75 | TDP1 (0.42) | TDP1 | |
| Tert-Butyl Formate SCHEMBL28325813 | 0.74 | TDP1 (0.50) | TDP1 | |
| Tert-Butyl Formate SCHEMBL27588067 | 0.72 | TDP1 (0.52) | TDP1 | |
| Tert-Butyl Formate SCHEMBL27857624 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105294699-B | Ba Rui replaces the preparation method of Buddhist nun | 上海勋和医药科技有限公司 | 2019-06-11 | — | — | CN | claimed |
| CN-108976233-A | Impurity and its preparation, detection method of the Ba Rui for Buddhist nun | 南京优科生物医药研究有限公司 | 2018-12-11 | — | — | CN | claimed |
| CN-105294699-A | Method for preparing baricitinib | SHANGHAI XUNHE PHARMACEUTICAL TECHNOLOGY CO LTD | 2016-02-03 | — | — | CN | claimed |
| CN-117720543-A | Preparation method of barytinib | 东北林业大学 | 2024-03-19 | — | — | CN | disclosed |
| CN-116375623-A | Novel synthesis method of baratinib and intermediate thereof | 浙江乐普药业股份有限公司 | 2023-07-04 | — | — | CN | disclosed |
| CN-115124537-A | Preparation method of JAK inhibitor britinib | 山东大学 | 2022-09-30 | — | — | CN | disclosed |
| CN-112898306-B | Preparation method of barretinib | 山东四环药业股份有限公司 | 2022-04-08 | — | — | CN | disclosed |
| CN-112898306-A | Preparation method of barretinib | 山东四环药业股份有限公司 | 2021-06-04 | — | — | CN | disclosed |
| CN-108586465-B | Preparation method of barretinib | 江苏中邦制药有限公司 | 2020-06-02 | — | — | CN | disclosed |
| CN-110446713-A | A kind of pyrazolopyrimidine derivative and application thereof and pharmaceutical composition | HANGZHOU AOJIN BIO MEDICINE TECH CO LTD | 2019-11-12 | — | — | CN | disclosed |
| CN-108137603-B | Azetidine derivatives, preparation method and the usage | 四川科伦博泰生物医药股份有限公司 | 2019-10-18 | — | — | CN | disclosed |
| CN-108137603-A | Azetidine derivatives, preparation method and the usage | 四川科伦博泰生物医药股份有限公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-107531695-A | JAK INHIBITORS | 无锡福祈制药有限公司 | 2018-01-02 | — | — | CN | disclosed |
| CN-106336413-A | Compounds used as JAK inhibitor, and use of compounds | 广东东阳光药业有限公司 | 2017-01-18 | — | — | CN | disclosed |
| CN-105452239-A | Bipyrazole derivatives as jak inhibitors | INCYTE CORP | 2016-03-30 | — | — | CN | disclosed |
| CN-103797010-B | As the azetidinyl phenyl of JAK inhibitor, pyridyl or pyrazinyl carboxamides derivatives | INCYTE HOLDINGS CORP. (US) | 2016-02-24 | — | — | CN | disclosed |
| CN-104024256-B | Methods and intermediates for preparing JAK inhibitors | INCYTE HOLDINGS CORP. (US) | 2016-02-10 | — | — | CN | disclosed |
| CN-105294699-A | Method for preparing baricitinib | SHANGHAI XUNHE PHARMACEUTICAL TECHNOLOGY CO LTD | 2016-02-03 | — | — | CN | disclosed |
| CN-105189509-A | Processes and intermediates for making a JAK inhibitor | INCYTE CORP | 2015-12-23 | — | — | CN | disclosed |
| CN-105189498-A | Geminally substituted cyanoethylpyrazolopyridinones as JANUS kinase inhibitors | MERCK SHARP & DOHME | 2015-12-23 | — | — | CN | disclosed |