Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MPI | P34949 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
| ▸ | ACE | P12821 | 1/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28153950 | 0.80 | DRD3 (0.37) | OPRK1DRD3 | |
| SCHEMBL30990313 | 0.73 | DRD3 (0.43) | HSD17B10OPRK1KDM4EALDH1A1MAPT | |
| Tetraxetan SCHEMBL6260240 | 0.71 | HSD17B10 (0.61) | HSD17B10SLC6A9KDM4EALDH1A1MAPT | |
| Tetraxetan SCHEMBL1880329 | 0.71 | HSD17B10 (0.61) | HSD17B10SLC6A9KDM4EALDH1A1MAPT | |
| SCHEMBL2422131 | 0.70 | HSD17B10 (0.50) | HSD17B10SLC6A9KDM4EALDH1A1MAPT | |
| SCHEMBL20994916 | 0.69 | USP30 (0.33) | OPRK1CYP1A2GRM5 | |
| SCHEMBL27166201 | 0.69 | ALDH1A1 (0.45) | OPRK1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL11427988 | 0.69 | HSD17B10 (0.48) | HSD17B10SLC6A9KDM4EALDH1A1MAPT | |
| SCHEMBL9693848 | 0.69 | HSD17B10 (0.48) | HSD17B10SLC6A9KDM4EALDH1A1MAPT | |
| Tetraxetan SCHEMBL18018 | 0.68 | HSD17B10 (0.64) | HSD17B10SLC6A9KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105189498-A | Geminally substituted cyanoethylpyrazolopyridinones as JANUS kinase inhibitors | MERCK SHARP & DOHME | 2015-12-23 | — | — | CN | disclosed |