Chalcone

Chalcone

SCHEMBL28027252

O=C(C=Cc1ccccc1)c1ccccc1.c1ccc(-c2ccccc2)cc1

nearest known ligand 0.88

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1B1 Q16678 11/20 0.88
MAPT P10636 6/20 0.88
MAOB P27338 5/20 0.88
LMNA P02545 2/20 0.88
BCHE P06276 2/20 0.88
TNFRSF1A P19438 2/20 0.88
PLIN1 O60240 1/20 0.88
ACHE P22303 1/20 0.88
RECQL P46063 1/20 0.88
PLIN5 Q00G26 1/20 0.88
ABHD5 Q8WTS1 1/20 0.88
CYP3A4 P08684 5/20 0.70
KMT2A Q03164 4/20 0.70
HSPD1 P10809 3/20 0.70
HSPE1 P61604 3/20 0.70
NFKB1 P19838 2/20 0.70
RAB9A P51151 2/20 0.70
NFKB2 Q00653 2/20 0.70
RELA Q04206 2/20 0.70
MEN1 O00255 2/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL657748 0.94 MAPT (0.78) CYP1B1MAPTMAOBLMNABCHE
SCHEMBL657749 0.94 MAPT (0.78) CYP1B1MAPTMAOBLMNABCHE
SCHEMBL14045042 0.94 CYP1B1 (0.78) CYP1B1MAPTMAOBLMNABCHE
SCHEMBL979407 0.94 CYP1B1 (0.78) CYP1B1MAPTMAOBLMNABCHE
Chalcone SCHEMBL27580 0.94 CYP1B1 (1.00) CYP1B1MAPTMAOBLMNABCHE
Chalcone SCHEMBL29396001 0.94 CYP1B1 (1.00) CYP1B1MAPTMAOBLMNABCHE
Chalcone SCHEMBL2404758 0.94 CYP1B1 (1.00) CYP1B1MAPTMAOBLMNABCHE
Chalcone SCHEMBL27581 0.94 CYP1B1 (1.00) CYP1B1MAPTMAOBLMNABCHE
Chalcone SCHEMBL454583 0.94 CYP1B1 (1.00) CYP1B1MAPTMAOBLMNABCHE
Chalcone SCHEMBL29922932 0.94 CYP1B1 (1.00) CYP1B1MAPTMAOBLMNABCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104945433-A Method for preparing cyclopropyl phosphonate ZHANGJIAGANG INST IND TECHNOLOGIES SOOCHOW UNIV 2015-09-30 CN disclosed