Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Uracil SCHEMBL151239 | 0.86 | — | — | |
| Uracil SCHEMBL27724117 | 0.85 | HSP90AA1 (0.37) | HSP90AA1 | |
| Uracil SCHEMBL27271010 | 0.84 | — | — | |
| Uracil SCHEMBL5182388 | 0.84 | — | — | |
| Uracil SCHEMBL28745089 | 0.84 | — | — | |
| Uracil SCHEMBL28281876 | 0.78 | — | — | |
| Biphenyl SCHEMBL27705553 | 0.78 | AURKA (0.44) | HSP90AA1 | |
| Uracil SCHEMBL15456754 | 0.77 | KDM4E (0.34) | — | |
| Pyrimidine SCHEMBL9443784 | 0.76 | CYP2A6 (0.33) | HSP90AA1CYP2A6 | |
| Uracil SCHEMBL6557359 | 0.76 | KDM4E (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105829315-A | Pyrimidopyrimidinones useful as Wee-1 kinase inhibitors | 阿尔麦克探索有限公司 | 2016-08-03 | — | — | CN | disclosed |
| CN-105209463-A | 2-aminopyrido[4,3-d]pyrimidin-5-one derivatives and their use as wee-1 inhibitors | ALMAC DISCOVERY LTD | 2015-12-30 | — | — | CN | disclosed |