Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6881940 | 0.83 | TSHR (0.50) | TSHRSMN1; SMN2KMT2AMEN1HTT | |
| SCHEMBL28044466 | 0.83 | ATM (0.50) | KMT2AMEN1ALDH1A1POLBMAPT | |
| SCHEMBL6630548 | 0.83 | TSHR (0.50) | TSHRSMN1; SMN2KMT2AMEN1HTT | |
| SCHEMBL28028204 | 0.81 | CNR2 (0.46) | TSHRSMN1; SMN2KMT2AMEN1HTT | |
| SCHEMBL7056381 | 0.80 | TSHR (0.53) | TSHRSMN1; SMN2KMT2AMEN1HTT | |
| SCHEMBL6574637 | 0.78 | TSHR (0.65) | TSHRSMN1; SMN2KMT2AMEN1HTT | |
| SCHEMBL121124 | 0.78 | TSHR (0.65) | TSHRSMN1; SMN2KMT2AMEN1HTT | |
| SCHEMBL2935426 | 0.78 | TSHR (0.51) | TSHRSMN1; SMN2KMT2AMEN1HTT | |
| SCHEMBL6628027 | 0.78 | TSHR (0.51) | TSHRSMN1; SMN2KMT2AMEN1HTT | |
| SCHEMBL6632225 | 0.78 | TSHR (0.51) | TSHRSMN1; SMN2KMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102014635-B | Difluoro-containing compounds as cysteine protease inhibitors | VIROBAY, INC. (US) | 2015-12-16 | — | — | CN | disclosed |
| CN-102417480-B | As the Spirocyclic nitriles of proteinase inhibitor | Sanofi-Aventis S. P. A. (FR) | 2015-08-26 | — | — | CN | disclosed |