Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 11/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.55 |
| ▸ | MTOR | P42345 | 10/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28298228 | 0.88 | PIK3CA (0.54) | PIK3CAPIK3CBPIK3CGPIK3CDMTOR | |
| SCHEMBL28029209 | 0.84 | PIK3CA (0.67) | PIK3CAPIK3CBPIK3CGPIK3CDMTOR | |
| SCHEMBL28028869 | 0.83 | PIK3CA (0.68) | PIK3CAPIK3CBPIK3CGPIK3CDMTOR | |
| SCHEMBL300729 | 0.83 | PIK3CD (0.78) | PIK3CAPIK3CBPIK3CGPIK3CDMTOR | |
| SCHEMBL28029216 | 0.82 | PIK3CD (0.49) | PIK3CAPIK3CBPIK3CGPIK3CDMTOR | |
| SCHEMBL28028896 | 0.81 | PIK3CD (0.49) | PIK3CAPIK3CBPIK3CGPIK3CDMTOR | |
| SCHEMBL28028870 | 0.79 | PIK3CB (0.47) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL28029240 | 0.78 | PIK3CB (0.48) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL28028885 | 0.78 | PIK3CA (0.58) | PIK3CAPIK3CBPIK3CGPIK3CDMTOR | |
| SCHEMBL28029218 | 0.77 | PIK3CG (0.60) | PIK3CAPIK3CBPIK3CGPIK3CDMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107976546-A | Inhibition of phosphorylation to TOR kinase inhibiting activities mark PRAS40, GSK3- β or P70S6K1 | 西格诺药品有限公司 | 2018-05-01 | — | — | CN | disclosed |
| CN-104870998-B | inhibition of phosphorylation of PRAS40, GSK3- β or P70S6K1 as a marker of TOR kinase inhibitory activity | 西格诺药品有限公司 | 2018-02-02 | — | — | CN | disclosed |
| CN-104870998-A | Inhibition of phosphorylation of PRAS40, GSK 3-beta or P70S6K1 as a marker of TOR kinase inhibitory activity | SIGNAL PHARM LLC | 2015-08-26 | — | — | CN | disclosed |