Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 15/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 15/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 15/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28029216 | 0.85 | PIK3CD (0.49) | PIK3CDPIK3CBPIK3CGPIK3CAMTOR | |
| SCHEMBL28821909 | 0.85 | PIK3CD (0.48) | PIK3CDPIK3CBPIK3CGPIK3CAMTOR | |
| SCHEMBL28028872 | 0.82 | TLR7 (0.49) | PIK3CDPIK3CBPIK3CGPIK3CAMTOR | |
| SCHEMBL300868 | 0.81 | PIK3CD (0.71) | PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL28028895 | 0.81 | PIK3CA (0.55) | PIK3CDPIK3CBPIK3CGPIK3CAMTOR | |
| SCHEMBL28029219 | 0.81 | PIK3CD (0.44) | PIK3CDPIK3CBPIK3CGPIK3CAKDM4E | |
| SCHEMBL28029229 | 0.80 | PIK3CD (0.47) | PIK3CDPIK3CBPIK3CGPIK3CAKDM4E | |
| SCHEMBL28028879 | 0.80 | PIK3CD (0.43) | PIK3CDPIK3CBPIK3CGPIK3CAMTOR | |
| SCHEMBL28029227 | 0.79 | PIK3CD (0.47) | PIK3CDPIK3CBPIK3CGPIK3CAKDM4E | |
| SCHEMBL28029206 | 0.78 | PIK3CD (0.48) | PIK3CDPIK3CBPIK3CGPIK3CAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104870998-A | Inhibition of phosphorylation of PRAS40, GSK 3-beta or P70S6K1 as a marker of TOR kinase inhibitory activity | SIGNAL PHARM LLC | 2015-08-26 | — | — | CN | disclosed |