Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14286834 | 0.88 | KARS1 (0.41) | KARS1MEN1TP53CYP3A4MAPT | |
| SCHEMBL14112200 | 0.88 | KARS1 (0.41) | KARS1MEN1TP53CYP3A4MAPT | |
| SCHEMBL14260996 | 0.88 | KARS1 (0.41) | KARS1MEN1TP53CYP3A4MAPT | |
| SCHEMBL12887769 | 0.88 | KARS1 (0.41) | KARS1MEN1TP53CYP3A4MAPT | |
| SCHEMBL10219384 | 0.88 | KARS1 (0.41) | KARS1MEN1TP53CYP3A4MAPT | |
| SCHEMBL10219385 | 0.88 | KARS1 (0.41) | KARS1MEN1TP53CYP3A4MAPT | |
| SCHEMBL12522483 | 0.88 | KARS1 (0.41) | KARS1MEN1TP53CYP3A4MAPT | |
| SCHEMBL12522482 | 0.88 | KARS1 (0.41) | KARS1MEN1TP53CYP3A4MAPT | |
| SCHEMBL280149 | 0.84 | NR1H3 (0.31) | NR1H3 | |
| SCHEMBL6009546 | 0.83 | KARS1 (0.38) | KARS1MEN1TP53CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133915-B2 | Interleukin-1 and tumor necrosis factor-α modulators; syntheses of such modulators and methods of using such modulators | NEREUS PHARMACEUTICALS, INC. (US) | 2012-03-13 | — | — | US | disclosed |