Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 8/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28029221 | 0.87 | PIK3CD (0.47) | PIK3CDPIK3CBPIK3CGPIK3CAKDM4E | |
| SCHEMBL28029228 | 0.87 | PIK3CD (0.48) | PIK3CDPIK3CBPIK3CGPIK3CAKDM4E | |
| SCHEMBL28029232 | 0.84 | PIK3CD (0.48) | PIK3CDPIK3CBPIK3CGPIK3CAKDM4E | |
| SCHEMBL28029206 | 0.84 | PIK3CD (0.48) | PIK3CDPIK3CBPIK3CGPIK3CAKDM4E | |
| SCHEMBL300875 | 0.83 | PIK3CD (0.67) | PIK3CDPIK3CBPIK3CGPIK3CAKDM4E | |
| SCHEMBL28028899 | 0.83 | PIK3CD (0.49) | PIK3CDPIK3CBPIK3CGPIK3CAALDH1A1 | |
| SCHEMBL28028867 | 0.83 | PIK3CD (0.46) | PIK3CDPIK3CBPIK3CGPIK3CAKDM4E | |
| SCHEMBL28029227 | 0.83 | PIK3CD (0.47) | PIK3CDPIK3CBPIK3CGPIK3CAKDM4E | |
| SCHEMBL28029229 | 0.82 | PIK3CD (0.47) | PIK3CDPIK3CBPIK3CGPIK3CAKDM4E | |
| SCHEMBL28029211 | 0.81 | PIK3CD (0.49) | PIK3CDPIK3CBPIK3CGPIK3CAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104870998-A | Inhibition of phosphorylation of PRAS40, GSK 3-beta or P70S6K1 as a marker of TOR kinase inhibitory activity | SIGNAL PHARM LLC | 2015-08-26 | — | — | CN | disclosed |