Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 8/20 | 0.55 |
| ▸ | USP2 | O75604 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | GLA | P06280 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL298237 | 0.83 | KDM4E (0.75) | CSNK2A1USP2TSHRMAPK1NPSR1 | |
| SCHEMBL15210094 | 0.78 | KDM4E (0.68) | CSNK2A1USP2TSHRMAPK1NPSR1 | |
| SCHEMBL301153 | 0.78 | CSNK2A1 (0.73) | CSNK2A1USP2TSHRMAPK1NPSR1 | |
| SCHEMBL28028878 | 0.77 | MTOR (0.48) | CSNK2A1USP2TSHRMAPK1NPSR1 | |
| SCHEMBL297362 | 0.77 | KDM4E (0.72) | CSNK2A1USP2TSHRMAPK1NPSR1 | |
| SCHEMBL300894 | 0.76 | PIK3CD (0.71) | CSNK2A1PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL297473 | 0.76 | KDM4E (0.73) | CSNK2A1USP2TSHRMAPK1NPSR1 | |
| SCHEMBL300901 | 0.76 | KDM4E (0.73) | CSNK2A1USP2TSHRMAPK1NPSR1 | |
| SCHEMBL28015906 | 0.76 | CSNK2A1 (0.89) | CSNK2A1USP2TSHRMAPK1NPSR1 | |
| SCHEMBL291568 | 0.76 | CSNK2A1 (0.64) | CSNK2A1USP2TSHRMAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104870998-A | Inhibition of phosphorylation of PRAS40, GSK 3-beta or P70S6K1 as a marker of TOR kinase inhibitory activity | SIGNAL PHARM LLC | 2015-08-26 | — | — | CN | disclosed |