Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28028882 | 0.90 | MTOR (0.59) | MTORKDM4EGLAALDH1A1SMN1; SMN2 | |
| SCHEMBL28821952 | 0.89 | MTOR (0.47) | MTORKDM4EGLAALDH1A1SMN1; SMN2 | |
| SCHEMBL28028874 | 0.88 | MTOR (0.47) | MTORKDM4EALDH1A1SMN1; SMN2GAA | |
| SCHEMBL28028876 | 0.86 | MTOR (0.46) | MTORKDM4EGLAALDH1A1SMN1; SMN2 | |
| SCHEMBL28029238 | 0.84 | MTOR (0.44) | MTORKDM4EALDH1A1SMN1; SMN2GAA | |
| SCHEMBL28029224 | 0.84 | MTOR (0.43) | MTORKDM4EGLAALDH1A1SMN1; SMN2 | |
| SCHEMBL28198777 | 0.83 | PIK3CA (0.44) | MTORALDH1A1USP2LMNATSHR | |
| SCHEMBL28029222 | 0.82 | CYP1A2 (0.54) | MTORGLAALDH1A1USP2LMNA | |
| SCHEMBL28028898 | 0.81 | MTOR (0.46) | MTORKDM4EALDH1A1SMN1; SMN2GAA | |
| SCHEMBL28948857 | 0.81 | GRIN1 (0.46) | MTORUSP2LMNATSHRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107976546-A | Inhibition of phosphorylation to TOR kinase inhibiting activities mark PRAS40, GSK3- β or P70S6K1 | 西格诺药品有限公司 | 2018-05-01 | — | — | CN | disclosed |
| CN-104870998-B | inhibition of phosphorylation of PRAS40, GSK3- β or P70S6K1 as a marker of TOR kinase inhibitory activity | 西格诺药品有限公司 | 2018-02-02 | — | — | CN | disclosed |
| CN-104870998-A | Inhibition of phosphorylation of PRAS40, GSK 3-beta or P70S6K1 as a marker of TOR kinase inhibitory activity | SIGNAL PHARM LLC | 2015-08-26 | — | — | CN | disclosed |