SCHEMBL28028935

SCHEMBL28028935

O=C(C(Cn1cncn1)c1cc(F)ccc1F)C(Cn1cncn1)c1cc(F)ccc1F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.46
CYP19A1 P11511 3/20 0.46
LMNA P02545 3/20 0.46
CYP2C9 P11712 3/20 0.46
CYP2C19 P33261 3/20 0.46
HSP90AA1 P07900 1/20 0.46
CYP11B1 P15538 1/20 0.46
CYP11B2 P19099 1/20 0.46
ADRA1A P35348 1/20 0.46
CYP51A1 Q16850 1/20 0.46
KMT2A Q03164 1/20 0.40
MC3R P41968 1/20 0.38
CYP2B6 P20813 1/20 0.38
CYP3A5 P20815 1/20 0.38
CYP3A7 P24462 1/20 0.38
MAPK1 P28482 1/20 0.38
CYP3A43 Q9HB55 1/20 0.38
CYP46A1 Q9Y6A2 1/20 0.38
CES2 O00748 1/20 0.38
CES1 P23141 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27956484 0.90 CYP3A4 (0.49) CYP3A4CYP19A1LMNACYP2C9CYP2C19
SCHEMBL27775612 0.84 CYP1A2 (0.42) CYP3A4CYP19A1CYP2C9CYP2C19KMT2A
SCHEMBL27602500 0.81 CYP19A1 (0.55) CYP3A4CYP19A1LMNACYP2C9CYP2C19
SCHEMBL28028936 0.80 CYP19A1 (0.44) CYP3A4CYP19A1LMNACYP2C9CYP2C19
SCHEMBL27905534 0.76 LMNA (0.47) CYP19A1LMNAHSP90AA1KMT2AMAPK1
SCHEMBL20365722 0.74 CYP3A4 (0.52) CYP3A4CYP19A1LMNACYP2C9CYP2C19
SCHEMBL3793619 0.73 CYP3A4 (0.51) CYP3A4CYP19A1LMNACYP2C9CYP2C19
SCHEMBL28282814 0.72 KMT2A (0.49) CYP3A4CYP19A1LMNAKMT2ASMN1; SMN2
SCHEMBL30788056 0.72 CYP3A4 (0.50) CYP3A4CYP19A1LMNACYP2C9CYP2C19
SCHEMBL8915775 0.72 CYP3A4 (0.50) CYP3A4CYP19A1LMNACYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104961695-A Preparation method of isavuconazole and ravuconazole intermediate CHENGDU SYNS PHARMACEUTICAL TECHNOLOGY CO LTD 2015-10-07 CN claimed
CN-106317044-A Method for manufacturing isavuconazole or ravuconazole 刘玫君 2017-01-11 CN disclosed
CN-104961695-A Preparation method of isavuconazole and ravuconazole intermediate CHENGDU SYNS PHARMACEUTICAL TECHNOLOGY CO LTD 2015-10-07 CN disclosed