Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGL | P35573 | 3/20 | 0.96 |
| ▸ | GAA | P10253 | 9/20 | 0.85 |
| ▸ | MGAM | O43451 | 3/20 | 0.85 |
| ▸ | SI | P14410 | 3/20 | 0.85 |
| ▸ | GBA1 | P04062 | 3/20 | 0.85 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.85 |
| ▸ | LCT | P09848 | 1/20 | 0.85 |
| ▸ | GBA2 | Q9HCG7 | 9/20 | 0.58 |
| ▸ | UGCG | Q16739 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13848050 | 0.98 | AGL (1.00) | AGLGAAMGAMSIGBA1 | |
| SCHEMBL6135753 | 0.98 | AGL (1.00) | AGLGAAMGAMSIGBA1 | |
| SCHEMBL6135379 | 0.98 | AGL (1.00) | AGLGAAMGAMSIGBA1 | |
| SCHEMBL2435218 | 0.98 | AGL (1.00) | AGLGAAMGAMSIGBA1 | |
| Miglitol SCHEMBL23892585 | 0.92 | GAA (1.00) | AGLGAAMGAMSIGBA1 | |
| Miglitol SCHEMBL682218 | 0.92 | GAA (1.00) | AGLGAAMGAMSIGBA1 | |
| Miglitol SCHEMBL20402709 | 0.92 | GAA (1.00) | AGLGAAMGAMSIGBA1 | |
| Miglitol SCHEMBL15269512 | 0.92 | GAA (1.00) | AGLGAAMGAMSIGBA1 | |
| Miglitol SCHEMBL6545551 | 0.92 | GAA (1.00) | AGLGAAMGAMSIGBA1 | |
| Miglitol SCHEMBL22593 | 0.92 | GAA (1.00) | AGLGAAMGAMSIGBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103265476-B | Azasugar quaternary ammonium salt compound and preparation method thereof and application | INSTITUTE OF CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2015-09-09 | — | — | CN | disclosed |