Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PDE6D | O43924 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29433522 | 1.00 | CYP19A1 (0.49) | CYP19A1TNKS2LMNAPDE6DALDH1A1 | |
| SCHEMBL2802917 | 1.00 | CYP19A1 (0.49) | CYP19A1TNKS2LMNAPDE6DALDH1A1 | |
| SCHEMBL2489537 | 0.80 | CYP19A1 (0.47) | CYP19A1 | |
| SCHEMBL2487177 | 0.80 | SLC6A2 (0.44) | CYP19A1KDM1A | |
| SCHEMBL19000834 | 0.79 | DDB1 (0.55) | TNKS2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL2492670 | 0.79 | TP53 (0.42) | TNKS2LMNAALDH1A1GAAKDM4E | |
| SCHEMBL8171790 | 0.79 | NPC1 (0.40) | CYP19A1LMNAALDH1A1KDM1ACYP1A2 | |
| SCHEMBL2484478 | 0.79 | DDB1 (0.47) | CYP19A1LMNAALDH1A1KDM4ECYP1A2 | |
| SCHEMBL19380843 | 0.79 | DDB1 (0.47) | CYP19A1LMNAALDH1A1KDM4ECYP1A2 | |
| SCHEMBL10725754 | 0.76 | CYP19A1 (0.52) | CYP19A1MEN1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189036-B1 | COMPOSITIONS AND METHODS FOR TREATING PROLIFERATION DISORDERS | ARQULE INC (US) | 2023-07-19 | — | — | EP | disclosed |
| EP-3189036-B1 | COMPOSITIONS AND METHODS FOR TREATING PROLIFERATION DISORDERS | ARQULE INC (US) | 2023-07-19 | — | — | EP | disclosed |
| CN-114874149-A | Process for preparing substituted 5, 6-dihydro-6-phenylbenzo [ F ] isoquinolin-2-amines | 艾科尔公司 | 2022-08-09 | — | — | CN | disclosed |
| EP-4015508-A1 | METHODS FOR PREPARING SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE | ArQule, Inc. (US) | 2022-06-22 | — | — | EP | disclosed |
| EP-4015508-A1 | METHODS FOR PREPARING SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE | ArQule, Inc. (US) | 2022-06-22 | — | — | EP | disclosed |
| US-11279679-B2 | Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine | ARQULE, INC. (US) | 2022-03-22 | — | — | US | disclosed |
| US-10766868-B2 | Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine | ARQULE, INC. (US) | 2020-09-08 | — | — | US | disclosed |
| US-10766868-B2 | Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine | ARQULE, INC. (US) | 2020-09-08 | — | — | US | disclosed |
| US-20200102276-A1 | METHODS FOR PREPARING SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE | ARQULE, INC. | 2020-04-02 | — | — | US | disclosed |
| US-20200102276-A1 | METHODS FOR PREPARING SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE | ARQULE, INC. | 2020-04-02 | — | — | US | disclosed |
| WO-2016037044-A1 | COMPOSITIONS AND METHODS FOR TREATING PROLIFERATION DISORDERS | ARQULE, INC. (US) | 2016-03-10 | — | — | WO | disclosed |
| US-20160067260-A1 | Compositions and Methods for Treating Proliferation Disorders | ARQULE, INC. | 2016-03-10 | — | — | US | disclosed |
| US-20160067260-A1 | Compositions and Methods for Treating Proliferation Disorders | ARQULE, INC. | 2016-03-10 | — | — | US | disclosed |
| EP-2379506-B1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS | ARQULE INC (US) | 2015-09-02 | — | — | EP | disclosed |
| EP-2379506-B1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS | ARQULE INC (US) | 2015-09-02 | — | — | EP | disclosed |
| US-8357694-B2 | Substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds | ARQULE, INC. (US) | 2013-01-22 | — | — | US | disclosed |
| US-8357694-B2 | Substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds | ARQULE, INC. (US) | 2013-01-22 | — | — | US | disclosed |
| US-8357694-B2 | Substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds | ARQULE, INC. (US) | 2013-01-22 | — | — | US | disclosed |
| US-20100239525-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS | ARQULE, INC. (US) | 2010-09-23 | — | — | US | disclosed |
| WO-2010078421-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F] ISOQUINOLIN-2-AMINE COMPOUNDS | ARQULE, INC. (US) | 2010-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10766868-B2 | Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine | QDPR, SFPQ, ABL1 | CYP19A1 1323/4885TNKS2 635/4885LMNA 808/4885 |
| US-20160067260-A1 | Compositions and Methods for Treating Proliferation Disorders | MKI67, HRAS, VHL | CYP19A1 1850/4885TNKS2 781/4885LMNA 625/4885 |
| US-11279679-B2 | Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine | QDPR, SFPQ, ABL1 | CYP19A1 1323/4885TNKS2 635/4885LMNA 808/4885 |
| US-20100239525-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS | NQO1, DPYD, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | CYP19A1 683/4885TNKS2 476/4885LMNA 1658/4885 |
| US-20200102276-A1 | METHODS FOR PREPARING SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE | QDPR, SFPQ, ABL1 | CYP19A1 1323/4885TNKS2 635/4885LMNA 808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.