Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.62 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | JAK1 | P23458 | 1/20 | 0.58 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.48 |
| ▸ | STS | P08842 | 1/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28030595 | 1.00 | USP30 (0.62) | USP30JAK2JAK1HSD11B1SIGMAR1 | |
| SCHEMBL7761338 | 1.00 | USP30 (0.62) | USP30JAK2JAK1HSD11B1SIGMAR1 | |
| SCHEMBL883610 | 0.94 | USP30 (0.55) | USP30JAK2JAK1HSD11B1SIGMAR1 | |
| SCHEMBL29782573 | 0.94 | USP30 (0.55) | USP30JAK2JAK1HSD11B1SIGMAR1 | |
| SCHEMBL803663 | 0.93 | JAK2 (0.54) | USP30JAK2JAK1SIGMAR1GPR119 | |
| SCHEMBL29418473 | 0.93 | SIGMAR1 (0.55) | USP30JAK2JAK1HSD11B1SIGMAR1 | |
| SCHEMBL3001865 | 0.91 | USP30 (0.57) | USP30JAK2JAK1HSD11B1SIGMAR1 | |
| SCHEMBL13243625 | 0.91 | USP30 (0.57) | USP30JAK2JAK1HSD11B1SIGMAR1 | |
| SCHEMBL29593677 | 0.91 | JAK2 (0.51) | USP30JAK2JAK1HSD11B1SIGMAR1 | |
| SCHEMBL13012605 | 0.90 | SMN1; SMN2 (0.57) | USP30SIGMAR1GPR119CCR5NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103764641-B | The tricyclic compound of fractional saturation and preparation and application thereof | 扎夫根股份有限公司 | 2016-10-26 | — | — | CN | disclosed |
| CN-104918615-A | Methods of treating liver diseases | ZAFGEN INC | 2015-09-16 | — | — | CN | disclosed |