Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | MPI | P34949 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3823764 | 0.87 | LMNA (0.55) | MAPTGAAKDM4EALDH1A1POLB | |
| SCHEMBL17115622 | 0.86 | LMNA (0.55) | MAPTGAAKDM4EALDH1A1POLB | |
| SCHEMBL15709871 | 0.82 | KDM4E (0.57) | MAPTGAAKDM4EALDH1A1POLB | |
| SCHEMBL7187027 | 0.80 | MAPT (0.56) | MAPTGAAKDM4EALDH1A1POLB | |
| SCHEMBL1493576 | 0.80 | MAPT (0.56) | MAPTLMNAMAPK1ARNPC1 | |
| SCHEMBL8183054 | 0.80 | LMNA (0.53) | MAPTKDM4EALDH1A1POLBMPI | |
| Hydrochloric Acid SCHEMBL5008552 | 0.79 | MAPT (0.54) | MAPTLMNAMAPK1ARNPC1 | |
| SCHEMBL1436135 | 0.77 | MAPT (0.59) | MAPTLMNAMAPK1ARNPC1 | |
| SCHEMBL15349288 | 0.77 | MAPT (0.56) | MAPTLMNAMAPK1ARNPC1 | |
| SCHEMBL18674655 | 0.77 | LMNA (0.58) | MAPTGAAALDH1A1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104936954-A | compounds and methods of use thereof | AGIOS PHARMACEUTICALS INC | 2015-09-23 | — | — | CN | disclosed |