Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | CCR8 | P51685 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tert-Butyl Formate SCHEMBL27464456 | 0.87 | TDP1 (0.54) | TDP1ALOX5APFEN1CCR1CCR5 | |
| Tert-Butyl Formate SCHEMBL27836114 | 0.78 | TDP1 (0.54) | TDP1 | |
| Tert-Butyl Formate SCHEMBL1671 | 0.77 | — | — | |
| Tert-Butyl Formate SCHEMBL30378535 | 0.77 | TDP1 (1.00) | TDP1 | |
| Tert-Butyl Formate SCHEMBL28106695 | 0.75 | TDP1 (0.81) | TDP1 | |
| Tert-Butyl Formate SCHEMBL4984399 | 0.74 | — | — | |
| Tert-Butyl Formate SCHEMBL15687802 | 0.74 | — | — | |
| Tert-Butyl Formate SCHEMBL9398245 | 0.74 | — | — | |
| Tert-Butyl Formate SCHEMBL28465801 | 0.74 | — | — | |
| Tert-Butyl Formate SCHEMBL27596802 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109476668-A | For treating 6,7- dihydro -4H- pyrazolo [1,5-a] pyrazine and 6,7- dihydro -4H- triazol [1,5-a] pyrazine compound of infectious diseases | 豪夫迈·罗氏有限公司 | 2019-03-15 | — | — | CN | disclosed |
| CN-109415368-A | For treating carboxyl 6,7- dihydro -4H- pyrazolo [1,5-a] pyrazine compound of infectious diseases | 豪夫迈·罗氏有限公司 | 2019-03-01 | — | — | CN | disclosed |
| CN-109096274-A | It can be used for treating the aryl-linking compound of human tumor, neurology and amynologic disease | 比奥根MA公司 | 2018-12-28 | — | — | CN | disclosed |
| CN-109071560-A | Thienopyridine formamide as ubiquitin-specific protease inhibitor | 福马治疗股份有限公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-108947913-A | It can be used for treating the aryl-linking compound of human tumor, neurology and amynologic disease | 比奥根MA公司 | 2018-12-07 | — | — | CN | disclosed |
| CN-106459002-A | Biaryl compounds useful in the treatment of human oncological, neurological and immunological diseases | 比奥根MA公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-104903325-A | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMA | 2015-09-09 | — | — | CN | disclosed |